Dosing: Adult

Neurocysticercosis: Oral:

<60 kg: 15 mg/kg/day in 2 divided doses (maximum: 800 mg/day) for 8-30 days

≥60 kg: 800 mg/day in 2 divided doses for 8-30 days

Note: Give concurrent anticonvulsant and steroid therapy during first week.

Hydatid: Oral:

<60 kg: 15 mg/kg/day in 2 divided doses (maximum: 800 mg/day)

≥60 kg: 800 mg/day in 2 divided doses

Note: Administer dose for three 28-day cycles with a 14-day drug-free interval in between each cycle.

Ancylostoma caninum, Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm) (unlabeled use): Oral: 400 mg as a single dose

Clonorchis sinensis (Chinese liver fluke) (unlabeled use): Oral: 10 mg/kg/day for 7 days

Cutaneous larva migrans (unlabeled use): Oral: 400 mg once daily for 3 days

Enterobius vermicularis (pinworm) (unlabeled use): Oral: 400 mg as a single dose; repeat in 2 weeks

Giardia duodenalis (giardiasis) (unlabeled use): Oral: 400 mg once daily for 5 days

Gnathostoma spinigerum (unlabeled use): Oral: 800 mg/day in 2 divided doses for 21 days

Gongylonemiasis (unlabeled use): Oral: 400 mg once daily for 3 days

Mansonella perstans (unlabeled use): Oral: 800 mg/day in 2 divided doses for 10 days

Oesophagostomum bifurcum (unlabeled use): Oral: 400 mg as a single dose (Ziem, 2004)

Trichinella spiralis (Trichinellosis) (unlabeled use): Oral: 800 mg/day in 2 divided doses for 8-14 days plus steroids for severe symptoms

Visceral larva migrans (toxocariasis) (unlabeled use): Oral: 800 mg/day in 2 divided doses for 5 days

Cysticercus cellulosae (unlabeled use): Oral: 800 mg/day in 2 divided doses for 8-30 days; may be repeated as necessary

Disseminated microsporidiosis (unlabeled use): Oral: 800 mg/day in 2 divided doses

Echinococcus granulosus (tapeworm) (unlabeled use): Oral: 800 mg/day in 2 divided doses for 1-6 months

Intestinal microsporidiosis (E. intestinalis) (unlabeled use): Oral: 800 mg/day in 2 divided doses for 21 days

Ocular microsporidiosis (unlabeled use): Oral: 800 mg/day in 2 divided doses, in combination with fumagillin

Dosing: Pediatric

Neurocysticercosis: Oral: Refer to adult dosing.

Hydatid: Oral: Refer to adult dosing.

Cysticercus cellulosae (unlabeled use): Oral: 15 mg/kg/day (maximum: 800 mg/day) in 2 divided doses for 8-30 days; may be repeated as necessary

Echinococcus granulosus (tapeworm) (unlabeled use): Oral: 15 mg/kg/day (maximum: 800 mg) divided twice daily for 1-6 months

Giardia duodenalis (giardiasis) (unlabeled use): Oral: 10 mg/kg/day for 5 days (Yereli, 2004)

Microsporidiosis (other than Enterocytozoon bienuesi or or V. corneae), disseminated or intestinal infection (HIV-positive, unlabeled use): Oral: Infants and Children: 15 mg/kg/day (maximum: 800 mg/day) in 2 divided doses continued until immune reconstitution after HAART initiation (CDC, 2009)

For the following unlabeled uses, refer to adult dosing: Ancylostoma caninum, Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), Clonorchis sinensis, (Chinese liver fluke), cutaneous larva migrans, Enterobius vermicularis (pinworm), Gnathostoma spinigerum, gongylonemiasis, Mansonella perstans, Necator americanus (hookworm), Oesophagostomum bifurcum, Trichinella spiralis (Trichinellosis), visceral larva migrans (toxocariasis)

Dosing: Geriatric

Refer to adult dosing.