Use

Oral: Adjunctive therapy for peptic ulcers, irritable bowel, neurogenic bladder/bowel; treatment of infant colic, GI tract disorders caused by spasm; to reduce rigidity, tremors, sialorrhea, and hyperhidrosis associated with parkinsonism; as a drying agent in acute rhinitis

Injection: Preoperative antimuscarinic to reduce secretions and block cardiac vagal inhibitory reflexes; to improve radiologic visibility of the kidneys; symptomatic relief of biliary and renal colic; reduce GI motility to facilitate diagnostic procedures (ie, endoscopy, hypotonic duodenography); reduce pain and hypersecretion in pancreatitis, certain cases of partial heart block associated with vagal activity; reversal of neuromuscular blockade

Adverse Reactions Sig

Dosing: Adult

Gastrointestinal spasms:

Oral or S.L.: 0.125-0.25 mg every 4 hours or as needed (before meals or food); maximum: 1.5 mg/24 hours

Oral, timed release: 0.375-0.75 mg every 12 hours; maximum: 1.5 mg/24 hours

I.M., I.V., SubQ: 0.25-0.5 mg; may repeat as needed up to 4 times/day, at 4-hour intervals

Diagnostic procedures: I.V.: 0.25-0.5 mg given 5-10 minutes prior to procedure

Preanesthesia: I.V.: 5 mcg/kg given 30-60 minutes prior to induction of anesthesia or at the time preoperative narcotics or sedatives are administered

To reduce drug-induced bradycardia during surgery: I.V.: 0.125 mg; repeat as needed

Reverse neuromuscular blockade: I.V.: 0.2 mg for every 1 mg neostigmine (or the physostigmine/pyridostigmine equivalent)

Dosing: Pediatric

Gastrointestinal disorders:

Children <2 years: Oral: Dose as listed, based on age and weight (kg) using the 0.125 mg/mL drops. Repeat dose every 4 hours as needed:

3.4 kg: 4 drops; maximum: 24 drops/24 hours

5 kg: 5 drops; maximum: 30 drops/24 hours

7 kg: 6 drops; maximum: 36 drops/24 hours

10 kg: 8 drops; maximum: 48 drops/24 hours

Children 2-12 years: Oral or S.L.: Dose as listed, based on age and weight (kg); repeat dose every 4 hours as needed:

10 kg: 0.031-0.033 mg; maximum: 0.75 mg/24 hours

20 kg: 0.0625 mg; maximum: 0.75 mg/24 hours

40 kg: 0.0938 mg; maximum: 0.75 mg/24 hours

50 kg: 0.125 mg; maximum: 0.75 mg/24 hours

Preanesthesia: Children >2 years: I.V.: Refer to adult dosing.

Dosing: Geriatric

Refer to adult dosing