Combinations; 1. Cyproheptadine/ L-Carnitine/ plus other nutrients
2. Cyproheptadine/ Tricholine
Dosage ; Allergies and pruritis:
Adult; 4mg TID (max. 32mg daily),7
-14 years; 4mg BD or TID (max. 8mg in 4-6 hours period).
Appetite stimulant: Oral, 4mg TID with meals.
Promotion of weight gain: treatment period should not exceed six months.
Vascular headache suppressant: Oral, 4 mg at the start of the attack,
repeated after thirty minutes if necessary.
Maintenance: Oral, 4 mg every four to six hours
Use;
Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria
Use - Unlabeled/Investigational
Migraine headache prophylaxis, pruritus, spasticity associated with spinal cord damage
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Periactin | MSD Ltd. | Surgipharm Ltd | 4mg | 100 | Tablet | per tablet | KES 406.00 |
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Cyproheptadine More info |
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|---|---|
| Mode Of Action | Antihistamine (H1) and serotonin antagonist such as cyproheptadine |
| Drug Indication | Allergies and pruritis; appetite stimulant; promotion of weight gain; suppression of vascular headache. |
| Precautions | May increase serum amylase and serum prolactin concentrations when administered with thyrotropin-releasing hormone (TRH) therefore affecting some laboratory values. |
| Contra-Indications | Newborn or premature infants; nursing mothers; hypersensitivity to cyproheptadine and other drugs of similar chemical structure; monoamine oxidase inhibitor therapy; angle-closure glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; bladder neck obstruction; pyloroduodenal obstruction; elderly, debilitated patients. |
| Side Effects | Blood dyscrasia after prolonged use, anaphylactic reaction, hepatitis, neurological and psychiatric disturbances, dry mouth, difficult in micturition and urine retention, Gl disturbances. |
| Dosage | Allergies and pruritis: Adult; 4mg TID (max. 32mg daily), 7-14 years; 4mg BD or TID (max. 8mg in 4-6 hours period). Appetite stimulant: Oral, 4mg TID with meals. Promotion of weight gain: treatment period should not exceed six months. Vascular headache suppressant: Oral, 4 mg at the start of the attack, repeated after thirty minutes if necessary. Maintenance: Oral, 4 mg every four to six hours |
| Pregnancy Category | Category A1: |
| Pregnancy Category Description | Drugs which have been taken by a sizeable number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. |
| Drug Category | ANTIALLERGIC & ANTIANAPHYLACTIC AGENTS |
| Drug Sub-Category | Sedating antihistamines
Pharmacologic Category Histamine H1; Antagonist Histamine H1; Antagonist, First Generation Piperidine Derivative Dosing: Adult Allergic conditions: Oral: 4-20 mg/day divided every 8 hours (not to exceed 0.5 mg/kg/day); some patients may require up to 32 mg/day for adequate control of symptoms Spasticity associated with spinal cord damage (unlabeled use): Oral: Initial: 2-4 mg every 8 hours; maximum: 8 mg every 8 hours (Barbeau, 1982; Wainberg, 1990) Dosing: Pediatric Allergic conditions: Oral: Children: 0.25 mg/kg/day or 8 mg/m2/day in 2-3 divided doses or 2-6 years: 2 mg every 8-12 hours (not to exceed 12 mg/day) 7-14 years: 4 mg every 8-12 hours (not to exceed 16 mg/day) Migraine headache prophylaxis (unlabeled use): Oral: 4 mg every 8-12 hours Dosing: Geriatric Initiate therapy at the lower end of the dosage range |
| Mode Of Action | Cyproheptadine is an antihistamine (H1) and serotonin antagonist that stimulates appetite and weight gain. L-carnitine is necessary for normal mammalian fat utilization and energy metabolism. L-Carnitine also stimulates GI and pancreatic secretions. L-lysine is important for protein synthesis. |
|---|---|
| Drug Indication | Anorexia and retardation of growth |
| Precautions | Bronchial asthma and lactation. |
| Contra-Indications | Glaucoma; urinary retention; stenosing peptic ulcer; acute asthma; elderly debilitated patients; concurrent administration of MAOIs; pylori-duodenal obstruction |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Periactin | Merck Sharp & Dohme | Phillips Pharmaceuticals Ltd. | 4mg | 100 | Tablet | per tablet | KES 706.00 |
| Uniactin | Pharmaceuticals Manufacturing Co. k Ltd. | Pharmaceutical Manufacturing Co.(K) Ltd | 4mg | 1000 | Tablet | per tablet | KES 520.00 |
| Uniactin | Pharmaceuticals Manufacturing Co. k Ltd. | Pharmaceutical Manufacturing Co.(K) Ltd | 2mg | 100ml | Syrup | per 5ML | KES 150.00 |
| Ciplactin | Cipla Ltd. | Surgipharm Ltd | 2mg | 100ml | Syrup | per 5ML | KES 138.00 |
| Ciplactin | Cipla Ltd. | Surgipharm Ltd | 4mg | 1000 | Tablet | per tablet | KES 2,020.00 |
2. Cyproheptadine/ Tricholine
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Cyprin | Oss Chemie Ltd | Unisel Pharma (K) Ltd. | 100ml | 1 | Syp | per Bottle | KES 120.00 |