Dosage ; Benign gastric and duodenal ulcer: 400mg BD or 800mg at bedtime: long-term treatment: 400mg Nocte.
Reflux oesophagitis: 800-1200mg divided into 2-4 daily doses.
Zollinger Ellison Syndrome: 400mg QID or more.
For hyperacidity, dyspepsia and heartburn:
100mg stat, repeat 100mg if symptoms persist for more than one hour
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Cimet | Flamingo Heat Pad | Harley's Limited | 400mg | 100 | Tablet | per tablet | KES 160 |
| Labcimet | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 400mg | 100 | Tablet | per tablet | KES 170 |
| Ulcidin | West Coast Pharmaceuticals Works Ltd | Ray Pharmaceuticals Ltd | 400mg | 100 | Tablet | per tablet | KES 500 |
| Ulmet | Universal Pharmaceuticals Ltd. | Europa Healthcare Ltd. | 400mg | 20 | Tablet | per tablet | KES 67 |
| Ulmet | Universal Pharmaceuticals Ltd. | Europa Healthcare Ltd. | 400mg | 100 | Tablet | per tablet | KES 258.00 |
| Cemet | Cosmos Limited. | Cosmos Limited | 200mg | 100 | Tablet | per tablet | KES 250.00 |
| Cemet | Cosmos Limited. | Cosmos Limited | 400mg | 100 | Tablet | per tablet | KES 500.00 |
| Cimet | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 400mg | 100 | Tablet | per tablet | KES 150.00 |
| Labcimet | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 400mg | 100 | Tablet | per tablet | KES 170.00 |
| Tagamet | GlaxoSmithkline | GlaxoSmithKline | 400mg | 20 | Tablet | per tablet | KES 160.00 |
| Cimetidine | |
|---|---|
| Mode Of Action | Histamine H2-receptor antagonist |
| Drug Indication | Reflux oesophagatis, benign gastric ulcer, duodenal ulcer and pathological hypersecretory conditions |
| Precautions | Impaired renal functions, diabetics, elderly, avoid concomitant use of anticoagulants e.g. warfarin, impairs spermatogenesis, children below 16 years, concomitant anticholinergic use, pregnancy and lactation (as safety not established). |
| Contra-Indications | Patients known to have hypersensitivity to the product |
| Side Effects | Masking of symptoms of gastric cancer, reversible gynaecomastia (weak anti-androgenic effect), alopecia, hepatic disorders, confusional states, galactorrhoea, blood disorders, loss of libido, acute pancreatitis, GI disturbances, skin rashes, cardiac arrhythmias, hypotension, muscular pain, nephritis, hallucinations |
| Dosage | Benign gastric and duodenal ulcer: 400mg BD or 800mg at bedtime: long-term treatment: 400mg Nocte. Reflux oesophagitis: 800-1200mg divided into 2-4 daily doses. Zollinger Ellison Syndrome: 400mg QID or more. For hyperacidity, dyspepsia and heartburn: 100mg stat, repeat 100mg if symptoms persist for more than one hour |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |