Histamine H2-receptor antagonist

Dosing: Adult

Duodenal ulcer: Oral: Treatment: 150 mg twice daily, or 300 mg once daily after the evening meal or at bedtime; maintenance: 150 mg once daily at bedtime

Eradication of Helicobacter pylori: Oral: 150 mg twice daily; requires combination therapy

Pathological hypersecretory conditions:

Oral: 150 mg twice daily; adjust dose or frequency as clinically indicated; doses of up to 6 g/day have been used

I.V.: Continuous infusion for Zollinger-Ellison: Initial: 1 mg/kg/hour; measure gastric acid output at 4 hours, if >10 mEq or if patient is symptomatic, increase dose in increments of 0.5 mg/kg/hour; doses of up to 2.5 mg/kg/hour (or 220 mg/hour) have been used

Gastric ulcer, benign: Oral: 150 mg twice daily; maintenance: 150 mg once daily at bedtime

GERD: Oral: 150 mg twice daily

Erosive esophagitis: Oral: Treatment: 150 mg 4 times/day; maintenance: 150 mg twice daily

Prevention of heartburn: Oral: Zantac 75® [OTC]: 75 mg 30-60 minutes before eating food or drinking beverages which cause heartburn; maximum: 150 mg in 24 hours; do not use for more than 14 days

Patients not able to take oral medication:

I.M.: 50 mg every 6-8 hours

I.V.: Intermittent bolus or infusion: 50 mg every 6-8 hours

Continuous I.V. infusion: 6.25 mg/hour

Dosing: Pediatric

(For additional information see "Ranitidine: Pediatric drug information")

Duodenal and gastric ulcer:

Oral: Children 1 month to 16 years:

Treatment: 4-8 mg/kg/day divided twice daily; maximum: 300 mg/day

Maintenance: 2-4 mg/kg/day once daily; maximum: 150 mg/day

I.V.: 2-4 mg/kg/day divided every 6-8 hours; maximum: 200 mg/day

GERD and erosive esophagitis: Children 1 month to 16 years:

Oral: 5-10 mg/kg/day divided twice daily; maximum: GERD: 300 mg/day, erosive esophagitis: 600 mg/day

I.V. (unlabeled): 2-4 mg/kg/day divided every 6-8 hours; maximum: 200 mg/day or as an alternative

Continuous infusion: Initial: 1 mg/kg/dose for one dose followed by infusion of 0.08-0.17 mg/kg/hour or 2-4 mg/kg/day

Prevention of heartburn: Oral: Children ≥12 years: Zantac 75® [OTC]: 75 mg 30-60 minutes before eating food or drinking beverages which cause heartburn; maximum: 150 mg/24 hours; do not use for more than 14 days

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment

Adults: Clcr <50 mL/minute:

Oral: 150 mg every 24 hours; adjust dose cautiously if needed

I.V.: 50 mg every 18-24 hours; adjust dose cautiously if needed

Hemodialysis: Adjust dosing schedule so that dose coincides with the end of hemodialysis.

Dosing: Hepatic Impairment

Patients with hepatic impairment may have minor changes in ranitidine half-life, distribution, clearance, and bioavailability; dosing adjustments are not necessary; monitor patient