Combinations ; See Below
1. Dihydroartemisinin / Piperaquine
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Arteximor | Sphinx Pharmaceuticals Ltd | Sphinx Pharmaceuticals Ltd | 160mg | 80ml | Suspension | per 5ML | KES 200.00 |
| Cotecxin | Holley-Cotec | Laborex Kenya Eurapharma Ltd | 60mg | 8 | Tablet | per tablet | KES 308.00 |
| Duo-Cotecxin | Holley-Cotec | Surgipharm Ltd | 20mg/160mg | 6 | Tablet | per tablet | KES 241.00 |
| Duo-Cotecxin | Holley-Cotec | Surgipharm Ltd | 40mg/320mg | 9 | Tablet | per tablet | KES 431.00 |
| Dihydroartemisinin More info | |
|---|---|
| Mode Of Action | Artemisinin derivatives are concentrated in the parasitized erythrocytes and it is believed that iron from ingested haemoglobin of the parasite?s victim reduces ?endoperoxide bridge? releasing a highly reactive free radical iron (IV) oxo species that rips apart the parasitic cells. |
| Drug Indication | Falciparum malaria, resistant malaria. |
| Contra-Indications | Early stages of pregnancy. |
| Side Effects | Temporary reticulocyte subsidence. |
| Dosage | Adult: 120mg in the first day, then 60mg OD x 4/7 or 6/7. 11-15yrs: 90mg stat then 45mg OD 4/7 or 6/7, 7-10yrs: 60mg stat, then 30mg OD 4/7 or 6/7 (max. 240mg), 4-6yrs: 40mg stat, then 20mg OD x 4/7 or 6/7 (max. 160mg), 1-3yrs: 30mg stat, then 15mg OD x 4/7 or 6/7 (max. 120mg), less than 1yr: 20mg stat, then 10mg OD x 4/7 or 6/7. |
| Pregnancy Category | Category B: |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Categorized further into: |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Malarials |
| 1. Dihydroartemisinin / Piperaquine | |
|---|---|
| Drug Indication | All forms of malaria, including severe malaria, cerebral malaria and multi-drug resistant malaria (provided that the patient can take medications orally). |
| Contra-Indications | First trimester of pregnancy (unless the risk of the disease is greater) as the ef-fects in pregnancy has not been fully established. A new course of the drug should not be taken within four weeks after the first treatment. |
| Side Effects | GI disturbances like nausea, diar-rhoea, loss of appetite; allegic reactions (though rare), temporary reticulocyte sub-sidence. |
| Dosage | 6 |
| Special Information | It is a synergistic combination of artemesinin derivative and a bisquinoline compound. The combination is active against the asexual forms of plasmodium, schizonts and gametocytes. The action of the combination on schizonts ensures a rapid decrease of pathogenic parasitaemia, which leads to a quick disappearance of clinical signs. The combination action on gametocytes prevents contamination. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Malarials |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Artequick | Artepharm Company Limited | Harley's Limited | 40mg/320mg | 4 | Tablet | per tablet | KES 450.00 |
| Co-santecxin | NIC Pharma | Medisel Kenya Ltd | 40mg/320mg | 9 | Tablet | per tablet | KES 221.00 |
| Co-Malasinin | Dawa Limited | Dawa Limited | 40mg/320mg | 8 | Tablet | per tablet | KES 260.00 |
| D-Artepp | Guilin Pharmaceuticals Ltd. | Pharma Specialities Ltd. | 40mg/320mg | 9 | Tablet | per tablet | KES 304.00 |
| Duo-Cotexin | Holley-Cotec | Surgipharm Ltd | 40mg/320mg | 8 | Tablet | per tablet | KES 400.00 |
| Duo-Cotexin | Holley-Cotec | Surgipharm Ltd | 40mg/320mg | 9 | Tablet | per tablet | KES 457.00 |
| Duo-Cotexin | Holley-Cotec | Surgipharm Ltd | 20mg/160mg | 6 | Tablet | per tablet | KES 300.00 |
| Duotab | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 40mg/320mg | 9 | Tablet | per tablet | KES 219.00 |
| Malacur | Apex Pharma Salvat | MacNaughton Limited | 40mg/320mg | 9 | Tablet | per tablet | KES 339.00 |
| Malacur | Apex Pharma Salvat | MacNaughton Limited | 90mg/270mg | 60ml | Tablet | per tablet | KES 333.00 |
| P. Alaxin | GVS Labs (See also Bliss GVS) | Pan Pharmaceuticals Ltd | 40mg/320mg | 9 | Tablet | per tablet | KES 285.00 |
| P. Alaxin | GVS Labs (See also Bliss GVS) | Pan Pharmaceuticals Ltd | 80mg/640mg | 80ml | Suspension | per 5ML | KES 285.00 |
| Ridmal | Ajanta Pharmaceuticals Ltd | Simba Pharmaceutical Ltd. | 40mg/320mg | 9 | Tablet | per tablet | KES 275.00 |