Combinations ; - see below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Amphotret | Bharat Biotech International Ltd | Pharma Specialities Ltd. | 50mg | 10ml | infusion | per ml | KES 320.00 |
| Amphotericin B More info | |
|---|---|
| Mode Of Action | Amphotericin probably acts by binding to the ergosterol in the fungal cell membrane causing membrane damage and subsequent leakage of cell contents. It has a higher affinity for ergosterol in the fungal cell membrane than in human. |
| Drug Indication | Progressive disseminated mycotic infections. |
| Precautions | Monitoring of renal function. |
| Contra-Indications | Avoid in patients known to be allergic to any of its constituents. |
| Side Effects | Anaphylactic shock; pseudomembranous colitis; nephrotoxicity; hepatoxicity; chills; fever; nausea and vomiting; encephalopathy; peripheral neuropathy. |
| Dosage | 0.25mg/kg, increasing to 1mg/kg by slow infusion in 5% glucose. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Fungals |