Combinations ; See Below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Vfend | Pfizer Global Pharmaceuticals | Laborex Kenya Eurapharma Ltd | 50mg | 30 | Tablet | per tablet | KES 8,791.00 |
| Vfend | Pfizer Global Pharmaceuticals | Laborex Kenya Eurapharma Ltd | 200mg | 30 | Tablet | per tablet | KES 36,374.00 |
| Vfend | Pfizer Global Pharmaceuticals | Laborex Kenya Eurapharma Ltd | 200mg | 1 | infusion | per ml | KES 4,453.00 |
| Voriconazole More info | |
|---|---|
| Mode Of Action | Fluconazole nhibits the fungal cytochrome P-450 3-A dependent enzyme, 14-alpha demethylase interrupting synthesis of ergosterol and resulting in increased cellular permeability and loss of cell contents |
| Drug Indication | Invasive aspergillosis; serious candidainfection like that of C. krusei; serious fungal infection in patients intolerant of, or refractory to other treatment. |
| Side Effects | Visual abnormalities and abnormal liver function tests; injection site reaction; hypotension; thrombocytopenia; anaemia; peripheral oedema; pulmonary oedema;fever; altered taste; respiratory distress syndrome. |
| Dosage | Adults: Loading dose: If IV, 6mg/kg every 12hrs for 24hrs. If oral and above 40kg - 400mg every 12hrs for 24hrs. If oral and below 40kg - 200mg every 12hrs for 24hrs. Maintenance: If IV, 3-4mg/kg every 12hrs. If oral and above 40kg - 200mg BD (max. 300mg BD). If oral and below 40kg - 100mg BD (max. 150mg BD).Children 2-12yrs: Round oral dose to the nearest 50mg. Loading dose: IV/oral, 6mg/kg every 12hrs for 24hrs. Maintenance: IV/oral, 4mg/kg every 12hrs for 24hrs. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Fungals |