Dose Adult
Usually administered in combination with beta-lactam antibiotics. Typical sulbactam dose: 0.5–1 g IV every 6–8 hours; total daily dose up to 4 g depending on the combination product and indication.
Dose Paeds
25–50 mg/kg/day (sulbactam component) IV in divided doses according to the accompanying antibiotic and infection severity.
Sulbactam Brands
| Brand | Combination | Formulation | Availability |
|---|---|---|---|
| Unasyn® | Ampicillin + Sulbactam | Injection | International |
| Sultamicillin | Ampicillin + Sulbactam | Tablet | International |
| Ampicillin/Sulbactam (Generic) | Ampicillin + Sulbactam | Injection | Available from various manufacturers |
| Cefoperazone/Sulbactam | Cefoperazone + Sulbactam | Injection | Available from various manufacturers |
| Sulbactam is marketed almost exclusively in fixed-dose combinations rather than as a single-agent product. | |||
Combinations
Commonly combined with Ampicillin, Cefoperazone and other beta-lactam antibiotics to inhibit beta-lactamase-producing bacteria.
| Sulbactam More action | |
|---|---|
| Indications | Used with beta-lactam antibiotics for respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, urinary tract infections, gynaecological infections and mixed aerobic/anaerobic infections. |
| Precautions | History of penicillin allergy, renal impairment, prolonged treatment, monitor liver and renal function where appropriate. |
| Contraindications | Known hypersensitivity to sulbactam, penicillins or other beta-lactam antibiotics. |
| Pregnancy/Lactation | Generally considered safe during pregnancy when indicated. Compatible with breastfeeding; use with clinical judgment. |
| Adverse reaction | Diarrhoea, nausea, rash, injection-site reactions, candidiasis, elevated liver enzymes, allergic reactions and anaphylaxis. |
| Polypharmacy | Monitor when used with anticoagulants, methotrexate and nephrotoxic drugs. Follow interaction guidance for the companion antibiotic. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Beta-Lactamase Inhibitors |