Dosage;
By mouth, adult and child over 8 years, 250-500mg every 6 hours or 0.5-1g every 12 hours;
up to 4g daily in divided doses in severe infections;
neonate 12.5mg/kg every 6 hours; child 1 month-2 years 125mg every 6 hours, 2-8 years 250mg every 6 hours,
doses doubled for severe infections.
Early syphilis, 500mg 4 times daily for 14 days.
Uncomplicated genital chlamydia, non-gonococcal urethritis, 500mg twice daily for 14 days.
Lyme disease, 500mg 4 times daily for 14-21 days.
By I.V infusion;
Adult and child severe infections, 50mg/kg daily by continuous infusion
or in divided doses every 6 hours; mild infections (oral treatment not possible), 25mg/kg daily.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Eryderm | Abbott Laboratories | Surgipharm Ltd | 2% | 60ml | solution | KES 687 | |
| Biotrocin | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 125mg | 60ml | Dry Suspension | per 5ML | KES 40.00 |
| Biotrocin | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 125mg | 100ml | Dry Suspension | per 5ML | KES 60.00 |
| Biotrocin | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 250mg | 100 | Tablet | per tablet | KES 450.00 |
| Biotrocin | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 250mg | 1000 | Tablet | per tablet | KES 4,000.00 |
| Elocin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 250mg | 100 | Tablet | per tablet | KES 350.00 |
| Elocin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 250mg | 500 | Tablet | per tablet | KES 1,500.00 |
| Elocin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 250mg | 1000 | Tablet | per tablet | KES 3,000.00 |
| Elocin | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 125mg | 100ml | Dry Suspension | per 5ML | KES 60.00 |
| Erilide | Plethico Pharma | Beta Healthcare International Ltd | 500mg | 100 | Tablet | per tablet | KES 650.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 250mg | 1000 | Tablet | per tablet | KES 3,100.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 250mg | 100 | Tablet | per tablet | KES 330.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 500mg | 100 | Tablet | per tablet | KES 630.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 125mg | 60ml | Suspension | per 5ML | KES 48.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 125mg | 100ml | Suspension | per 5ML | KES 60.00 |
| Erocin | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 250mg | 60ml | Suspension | per 5ML | KES 75.00 |
| Erocos | Cosmos Limited. | Cosmos Limited | 500mg | 100 | Tablet | per tablet | KES 1,600.00 |
| Erocos-ST | Cosmos Limited. | Cosmos Limited | 125mg | 100ml | Suspension | per 5ML | KES 165.00 |
| Eromycin | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 125mg | 100ml | Suspension | per 5ML | KES 175.00 |
| Eromycin | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 500mg | 30 | Tablet | per tablet | KES 500.00 |
| Erycin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 250mg | 100 | Tablet | per tablet | KES 260.00 |
| Erycin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 250mg | 1000 | Tablet | per tablet | KES 3,200.00 |
| Erycin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 500mg | 100 | Tablet | per tablet | KES 515.00 |
| Erycin | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 500mg | 500 | Tablet | per tablet | KES 1,950.00 |
| Erythro | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 250mg | 1000 | Tablet | per tablet | KES 5,286.00 |
| Erythromycin | Panacea International 105 | Europa Healthcare Ltd. | 250mg | 1000 | Tablet | per tablet | KES 2,800.00 |
| Erythromycin | Panacea International 105 | Europa Healthcare Ltd. | 250mg | 100 | Tablet | per tablet | KES 350.00 |
| Erythrocin | Medopharm Ltd. | Medox Pharmaceuticals Ltd. | 25mg | 100 | Tablet | per tablet | KES 385.00 |
| Erythrocin | Medopharm Ltd. | Medox Pharmaceuticals Ltd. | 25mg | 1000 | Tablet | per tablet | KES 3,600.00 |
| Erythromax | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 250mg | 100 | Capsule | per capsule | KES 540.00 |
| Erythromax | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 250mg | 500 | Capsule | per capsule | KES 2,400.00 |
| Erythromycin | Regal Pharmaceuticals | Ray Pharmaceuticals Ltd | 250mg | 100 | Capsule | per capsule | KES 539.00 |
| Erythroriv | Riva Pharma S.A.E | Salama Pharmaceuticals Ltd. | 125mg | 100ml | Syrup | per 5ML | KES 195.00 |
| Erythrox | Dawa Limited | Dawa Limited | 250mg | 100 | Tablet | per tablet | KES 370.00 |
| Erythrox | Dawa Limited | Dawa Limited | 250mg | 1000 | Tablet | per tablet | KES 3,000.00 |
| Erythrox | Dawa Limited | Dawa Limited | 500mg | 100 | Tablet | per tablet | KES 680.00 |
| Erythrox | Dawa Limited | Dawa Limited | 125mg | 60ml | Suspension | per 5ML | KES 40.00 |
| Erythrox | Dawa Limited | Dawa Limited | 125mg | 100ml | Suspension | per 5ML | KES 56.00 |
| Erythyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 250mg | 500 | Capsule | per capsule | KES 2,310.00 |
| Erythyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 125mg | 60ml | Dry Suspension | per 5ML | KES 77.00 |
| Erythyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 125mg | 100ml | Dry Suspension | per 5ML | KES 110.00 |
| Ethro | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 250mg | 100 | Tablet | per tablet | KES 348.00 |
| Ethro | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 250mg | 1000 | Tablet | per tablet | KES 3,267.00 |
| Ethro | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 500mg | 100 | Tablet | per tablet | KES 621.00 |
| Ethro | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 125mg | 100ml | Suspension | per 5ML | KES 74.00 |
| Etocin | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 250mg | 100 | Tablet | per tablet | KES 1,120.00 |
| Etocin | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 250mg | 1000 | Tablet | per tablet | KES 9,600.00 |
| Etocin | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 500mg | 100 | Tablet | per tablet | KES 1,380.00 |
| Etocin | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 500mg | 1000 | Tablet | per tablet | KES 12,000.00 |
| Etocin | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 125mg | 100ml | Dry Suspension | per 5ML | KES 100.00 |
| Indo | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 250mg | 100 | Tablet | per tablet | KES 500.00 |
| Indo | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 250mg | 1000 | Tablet | per tablet | KES 4,500.00 |
| Indo | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 500mg | 100 | Tablet | per tablet | KES 1,000.00 |
| Medithrocin | Medivet Products Ltd | Medivet Products Ltd. | 125mg | 60ml | Dry Suspension | per 5ML | KES POR |
| Throcin | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 250mg | 100 | Tablet | per tablet | KES 300.00 |
| Throcin | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 250mg | 1000 | Tablet | per tablet | KES 2,800.00 |
| Throcin | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 500mg | 100 | Tablet | per tablet | KES 550.00 |
| Erythromycin more info | |
|---|---|
| Mode Of Action | binds to 50s sub-unit of the bacterial ribosome and inhibits bacterial protein synthesis by preventing attachment of aminoacyl transfer RNA to its acceptor site on the ribosome. This prevents peptide bond formation by peptidyl transferase. |
| Drug Indication | An alternative for penicillin-allergic patients; intestinal amoebiasis, chlamydial, mycoplasmal infections, URTI, LRTI, skin and soft tissue infections, gonococcal male urethritis and female pelvic infections, long term prophylaxis of rheumatic fever, early syphillis in penicillin allergic patients, tetanus, legionnaires disease. |
| Precautions | Lactation, impaired hepatic functions. Do not give together with chloramphenicol, pregnancy especially first trimester, monitor prothrombin times during coumarin-type anti-coagulant concommitant therapy. |
| Contra-Indications | Terfenadine, astemizole, cisapride, impaired liver functions, jaundice and syphilis in pregnancy. |
| Side Effects | Pseudomembranous colitis, GI disturbances, allergic reactions, reversible hearing loss, super-infections, ventricular arrythmias with prolonged QT interval, agranulocytosis, myasthenia-like syndrome, pancreatitis, Stevens-Johnson and toxic epidermal necrolysis, hepatic dysfunctions, fever. |
| Dosage | By mouth, adult and child over 8 years, 250-500mg every 6 hours or 0.5-1g every 12 hours; up to 4g daily in divided doses in severe infections; neonate 12.5mg/kg every 6 hours; child 1 month-2 years 125mg every 6 hours, 2-8 years 250mg every 6 hours, doses doubled for severe infections.Early syphilis, 500mg 4 times daily for 14 days. Uncomplicated genital chlamydia, non-gonococcal urethritis, 500mg twice daily for 14 days. Lyme disease, 500mg 4 times daily for 14-21 days. By I.V infusion, adult and child severe infections, 50mg/kg daily by continuous infusion or in divided doses every 6 hours; mild infections (oral treatment not possible), 25mg/kg daily. |
| Pregnancy Category | Category B: |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Categorized further into: |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Macrolides |
Specific Dosing: Adult
Note: Due to differences in absorption, 400 mg erythromycin ethylsuccinate produces the same serum levels as 250 mg erythromycin base or stearate.
Usual dosage range:
Oral:
Base: 250-500 mg every 6-12 hours
Ethylsuccinate: 400-800 mg every 6-12 hours
I.V.: Lactobionate: 15-20 mg/kg/day divided every 6 hours or 500 mg to 1 g every 6 hours, or given as a continuous infusion over 24 hours (maximum: 4 g/24 hours)
Indication-specific dosing:
Bartonella sp infections (bacillary angiomatosis [BA], peliosis hepatis [PH]) (unlabeled use): Oral: 500 mg (base) 4 times/day for 3 months (BA) or 4 months (PH)
Chancroid (unlabeled use): Oral: 500 mg (base) 3 times/day for 7 days; Note: Not a preferred agent; isolates with intermediate resistance have been documented (CDC, 2010)
Gastrointestinal prokinetic (unlabeled use): I.V.: 200 mg initially followed by 250 mg (base) orally 3 times/day 30 minutes before meals. Lower dosages have been used in some trials.
Granuloma inguinale (donovanosis) (unlabeled use): Oral: 500 mg (base) 4 times/day for 21 days (CDC, 2010)
Legionnaires’ disease: Oral: 1.6-4 g (ethylsuccinate)/day or 1-4 g (base)/day in divided doses for 21 days. Note: No longer preferred therapy and only used in nonhospitalized patients
Lymphogranuloma venereum: Oral: 500 mg (base) 4 times/day for 21 days; Note: Preferred therapy for pregnant or lactating women (CDC, 2010)
Nongonococcal urethritis (including coinfection with C. trachomatis): Oral: 500 mg (base) 4 times/day for 7 days or 800 mg (ethylsuccinate) 4 times/day for 7 days. Note: May use 250 mg (base) or 400 mg (ethylsuccinate) 4 times/day for 14 days if gastrointestinal intolerance.
Pertussis: Oral: 500 mg (base) every 6 hours for 14 days
Preop bowel preparation: Oral: 1 g erythromycin base at 1, 2, and 11 PM on the day before surgery combined with mechanical cleansing of the large intestine and oral neomycin
Dosing: Pediatric
(For additional information see "Erythromycin (systemic): Pediatric drug information")
Note: Due to differences in absorption, 400 mg erythromycin ethylsuccinate produces the same serum levels as 250 mg erythromycin base or stearate.
Usual dosage range: Infants and Children:
Oral:
Base: 30-50 mg/kg/day in 2-4 divided doses; maximum: 2 g/day
Ethylsuccinate: 30-50 mg/kg/day in 2-4 divided doses; maximum: 3.2 g/day
Stearate: 30-50 mg/kg/day in 2-4 divided doses; maximum: 2 g/day
I.V.: Lactobionate: 15-50 mg/kg/day divided every 6 hours, not to exceed 4 g/day
Indication-specific dosing:
Bartonella sp infections (bacillary angiomatosis [BA], peliosis hepatis [PH]) (unlabeled use): Oral: 40 mg/kg/day (ethylsuccinate) in 4 divided doses (maximum: 2 g/day) for 3 months (BA) or 4 months (PH)
Chlamydial infection (C. trachomatis): Children <45 kg: Oral: 50 mg/kg/day (base or ethylsuccinate) in 4 divided doses for 14 days (CDC, 2010)
Conjunctivitis, neonatal (C. trachomatis): Oral: 50 mg/kg/day (base or ethylsuccinate) in 4 divided doses for 14 days
Mild/moderate infection: Oral: 30-50 mg/kg/day in divided doses every 6-12 hours
Pertussis: Oral: 40-50 mg/kg/day in 4 divided doses for 14 days; maximum 2 g/day (not preferred agent for infants <1 month due to IHPS)
Pharyngitis, tonsillitis (streptococcal): Oral: 20 mg (base)/kg/day or 40 mg (ethylsuccinate)/kg/day in 2 divided doses for 10 days. Note: No longer preferred therapy due to increased organism resistance.
Pneumonia (C. trachomatis): Infants: Oral: 50 mg/kg/day (base or ethylsuccinate) in 4 divided doses for 14 days (CDC, 2010)
Preop bowel preparation: Oral: 20 mg (base)/kg at 1, 2, and 11 PM on the day before surgery combined with mechanical cleansing of the large intestine and oral neomycin
Severe infection: I.V.: 15-50 mg/kg/day; maximum: 4 g/day
Dosing: Geriatric
Refer to adult dosing.
Dosing: Renal Impairment
Slightly dialyzable (5% to 20%); supplemental dose is not necessary in hemo- or peritoneal dialysis or in continuous arteriovenous or venovenous hemofiltration