Chloramphenicol

2. Chloramphenicol ear drops

3. Chloramphenicol eye drops

Chloramphenicol Brands

Brand Name	Manufacturer Name	Distributor	Drug Strength	Packaging	Formulation	Formulation Strength	Price
Aurocol	Aurolab	Medisel Kenya Ltd	0.50%	10ml	eye drops	per ml	KES 45
Chloramphenicol	Martindale Pharmaceuticals	Laborex Kenya Eurapharma Ltd	0.50%	10ml	Drops		KES 192.00
Chloramphenicol	Martindale Pharmaceuticals	Laborex Kenya Eurapharma Ltd	0.50%	10ml	Drops		KES 192.00
Ivyphenicol	Ivee Aqua EPZ Ltd.	Harley's Limited	0.50%	10ml	Drops		KES 17.00
Metamycin	B. D. H.	Medisel Kenya Ltd	0.50%	10ml	eye drops	per ml	KES 15
Nicol	West Coast Pharmaceuticals Works Ltd	Ray Pharmaceuticals Ltd	0.50%	5ml	eye drops	per ml	KES 26.88
Amphenical	OSS-Chemie k Ltd	Oss-Chemie (K) Ltd	125mg	60ml	Suspension	per 5ML	KES 33.00
Amphenical	OSS-Chemie k Ltd	Oss-Chemie (K) Ltd	125mg	100ml	Suspension	per 5ML	KES 55.00
Biophenicol	Biodeal Laboratories Ltd.	Biodeal Laboratories Ltd.	250mg	100	Capsule	per capsule	KES 320.00
Biophenicol	Biodeal Laboratories Ltd.	Biodeal Laboratories Ltd.	250mg	1000	Capsule	per capsule	KES 2,800.00
Biophenicol	Biodeal Laboratories Ltd.	Biodeal Laboratories Ltd.	125mg	60ml	Suspension	per 5ML	KES 40.00
Biophenicol	Biodeal Laboratories Ltd.	Biodeal Laboratories Ltd.	125mg	100ml	Suspension	per 5ML	KES 60.00
Chloramphenicol	Dawa Limited	Dawa Limited	250mg	1000	Capsule	per capsule	KES 2,800.00
Chloramphenicol	Flamingo Pharmaceuticals Ltd.	Harley's Limited	1g	1	Injection	per vial	KES 29.00
Chloramphenicol	Macleods Pharmaceuticals Ltd.	Sai Pharmaceuticals Ltd.	1g	1	Injection	per vial	KES 45.00
Chloramphenicol	Prism Life Sciences	Galaxy Pharmaceuticals Ltd	1g	1	Injection	per vial	KES 40.00
Chlorocide	Regal Pharmaceuticals	Regal Pharmaceuticals Limited	250mg	1000	Capsule	per capsule	KES 957.00
Chlorocide	Regal Pharmaceuticals	Regal Pharmaceuticals Limited	125mg	60ml	Suspension	per 5ML	KES 57.00
Chlorocide	Regal Pharmaceuticals	Regal Pharmaceuticals Limited	125mg	100ml	Suspension	per 5ML	KES 82.00
Dawaphenicol	Dawa Limited	Dawa Limited	250mg	1000	Capsule	per capsule	KES 2,800.00
Dawaphenicol	Dawa Limited	Dawa Limited	125mg	60ml	Suspension	per 5ML	KES 40.00
Dawaphenicol	Dawa Limited	Dawa Limited	125mg	100ml	Suspension	per 5ML	KES 60.00
Elycetin	Elys Chemicals Industries Ltd.	Elys Chemical Industries Ltd.	250mg	100	Capsule	per capsule	KES 260.00
Elycetin	Elys Chemicals Industries Ltd.	Elys Chemical Industries Ltd.	250mg	1000	Capsule	per capsule	KES 2,200.00
Elycetin	Elys Chemicals Industries Ltd.	Elys Chemical Industries Ltd.	125mg	60ml	Suspension	per 5ML	KES 25.00
Elycetin	Elys Chemicals Industries Ltd.	Elys Chemical Industries Ltd.	125mg	60ml	Syrup	per 5ML	KES 50.00
Elycetin	Elys Chemicals Industries Ltd.	Elys Chemical Industries Ltd.	125mg	100ml	Syrup	per 5ML	KES 77.00
Kloran	Sphinx Pharmaceuticals Ltd	Sphinx Pharmaceuticals Ltd	125mg	60ml	Suspension	per 5ML	KES 40.00
Kloran	Sphinx Pharmaceuticals Ltd	Sphinx Pharmaceuticals Ltd	125mg	100ml	Suspension	per 5ML	KES 50.00
Maxamycetin	Macs Pharmaceuticals	Mac?s Pharmaceuticals Ltd	250mg	1000	Capsule	per capsule	KES 2,400.00
Maxamycetin	Macs Pharmaceuticals	Mac?s Pharmaceuticals Ltd	125mg	60ml	Suspension	per 5ML	KES 31.00
Maxamycetin	Macs Pharmaceuticals	Mac?s Pharmaceuticals Ltd	1g	1	Injection	per vial	KES 18.00
Mediphenicol	Medivet Products Ltd	Medivet Products Ltd.	125mg	60ml	Suspension	per 5ML	KES POR
Oramnicol	Laboratory & Allied Ltd.	Laboratory & Allied Ltd	250mg	1000	Capsule	per capsule	KES 2,200.00
Oramnicol	Laboratory & Allied Ltd.	Laboratory & Allied Ltd	1g	1	Injection	per vial	KES 38.00
Tyde-S	Neon Laboratories Ltd	Sai Pharmaceuticals Ltd.	1g	1	Injection	per vial	KES 133.00
Xepaphenicol	Xepa-Soul Pattinson	Goodman Agencies Ltd	0.50%	60ml	Drops		KES 1,580.00

Chloramphenicol More info

Mode Of Action

binds to 50s sub-unit of the bacterial ribosome and inhibits bacterial protein synthesis by preventing attachment of aminoacyl transfer RNA to its acceptor site on the ribosome. This prevents peptide bond formation by peptidyl transferase.

Drug Indication

Serious infections where less potentially dangerous medicines are ineffective or contraindicated e.g. typhoid and paratyphoid fever, infections due to H. influenzae.

Precautions

Do routine blood examination, change parenteral administration to oral therapy as soon as possible, impaired liver and kidney functions. Must not be used in the treatment of trivial infections. Plasma concentration monitoring required in neonates and preferred in those under 4 years of age, in the elderly, and in hepatic impairment; recommended peak plasma concentration (approx. 1 hour after intravenous injection or infusion) 15-25mg/litre; pre-dose (trough') concentration should not exceed 15mg/litre.

Contra-Indications

Pregnancy, lactation, prophylaxis, active immunisation, porphyria, only in infants and in life threatening infections.

Side Effects

Bone marrow depression, blood dyscrasias especially fatal aplastic anaemia, gray syndrome in premature and inborn babies, optic and peripheral neuritis, GI disturbances, super-infection, hypersensitivity reactions.

Dosage

By mouth or by intravenous injection or infusion, 50mg/kg daily in 4 divided doses (exceptionally, can be doubled for severe infections such as septicaemia and meningitis, providing high doses reduced as soon as clinically indicated); child, haemophilus epiglottitis and pyogenic meningitis, 50-100mg/kg daily in divided doses (high dosages decreased as soon as clinically indicated); neonate under 2 weeks 25mg/kg daily (in 4 divided doses); infant 2 weeks-1 year 50mg/kg daily (in 4 divided doses).

Pregnancy Category

Category C

Pregnancy Category Description

Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible

Drug Category

DRUGS ACTING ON INFECTIONS

Drug Sub-Category

Other Antibiotics

Chloramphenicol ear drops
Drug Indication	Bacterial infections of the ear
Contra-Indications	Previous or existing blood dyscrasia
Side Effects	Sometimes, short-lasting burning feeling in the ear, aplastic anaemia (very rarely)
Dosage	Side effects: Sometimes, short-lasting burning feeling in the ear, aplastic anaemia (very rarely)
Drug Category	DRUGS ACTING ON ENT
Drug Sub-Category	Drugs acting in the ear

Brand Name	Manufacturer Name	Distributor	Drug Strength	Packaging	Formulation	Formulation Strength	Price
Biophenicol	Biodeal Laboratories Ltd.	Biodeal Laboratories Ltd.	5%	10ml	ear drops		KES 30.00
Chloricide	Regal Pharmaceuticals	Regal Pharmaceuticals Limited	5%	10ml	ear drops		KES 39
Clomex	Pharmaceuticals Manufacturing Co. k Ltd.	Pharmaceutical Manufacturing Co.(K) Ltd	5%	10ml	ear drops		KES 40.00
Ephenical	OSS-Chemie k Ltd	Njimia Pharmaceuticals Ltd.	5%	10ml	ear drops		KES 33.00
Ivychlornicol	Ivee Aqua EPZ Ltd.	Harley's Limited	5%	10ml	ear drops		KES 45.00
Mediphenicol	Medivet Products Ltd	Medivet Products Ltd.	5%	10ml	ear drops		KES POR
SQ-Mycetin	Square Pharmaceuticals Ltd	ACE Pharmaceuticals Ltd	0.50%	10ml	ear drops		KES 80.00
SQ-Mycetin	Square Pharmaceuticals Ltd	ACE Pharmaceuticals Ltd	0.50%	10ml	eye drops	per ml	KES 80.00
Kloran	Sphinx Pharmaceuticals Ltd	Sphinx Pharmaceuticals Ltd	5%	15ml	ear drops		KES 30.00

Chloramphenicol eye drops
Mode Of Action	binds to 50s sub-unit of the bacterial ribosome and inhibits bacterial protein synthesis by preventing attachment of aminoacyl transfer RNA to its acceptor site on the ribosome. This prevents peptide bond formation by peptidyl transferase.
Drug Indication	Susceptible eye infections
Precautions	Avoid long and repeated courses, routine blood examination, impaired hepatic/ renal functions.
Contra-Indications	Prophylaxis of bacterial infections, for minor infections, active immunization, newborn infants, pregnancy and lactation, patients on bone marrow depressant drugs
Side Effects	Bone marrow depression, haemolytic anaemia in G6PD deficiency, hypersensitivity reactions, optic atrophy, optic and peripheral neuritis, blindness, gray syndrome
Drug Category	OPHTHALMIC DRUGS
Drug Sub-Category	Antibacterial ophthalmic drugs