Dosage;
Oral dose: 0.5 to 1g every 6 to 8 hours.
Higher doses have been given parenterally as the sodium salt,
with up to 20g daily having been given I.V in severe infection.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Focin | Tabros Pharma (PVT) Ltd. | Globe Pharmacy Ltd., | 500mg | 10 | Capsule | per capsule | KES 312.00 |
| Focin | Tabros Pharma (PVT) Ltd. | Globe Pharmacy Ltd., | 250mg | 60ml | Suspension | per 5ML | KES 240.00 |
| Fosfomycin more info | |
|---|---|
| Mode Of Action | Interference with the first step in the synthesis of bacterial cell wall due to its inactivation of the enzyme enolpyruvyl transferase, thereby irreversibly blocking the condensation of uridine diphosphate-N-acetylglucosamine with p-enol-pyruvate, one of the first steps in bacterial cell wall synthesis. It also reduces adherence of bacteria to uroepithelial cells. |
| Drug Indication | Acute uncomplicated lower UTI, prophylactic use in transurethral procedures. |
| Precautions | Renal impairment, pregnancy and lactation. |
| Side Effects | GI disturbances like nausea, vomiting and diarrhoea. |
| Dosage | Oral dose: 0.5 to 1g every 6 to 8 hours. Higher doses have been given parenterally as the sodium salt, with up to 20g daily having been given I.V in severe infection. |
| Pregnancy Category | Category B: |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Categorized further into: |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Other Antibiotics |