Nitrofurantoin

Dosage;

Acute uncomplicated infection,

50mg every 6 hours with food for 7 days (3 days usually adequate in women);

Child over 3 months, 3mg/kg daily in 4 divided doses.

Severe chronic recurrent infection, 100mg every 6 hours with food for 7 days

(dose reduced or discontinued if severe nausea).

Prophylaxis, 50-100mg at night; child over 3 months, 1mg/kg at night.

Nitrofurantoin Brands
Brand Name Manufacturer Name Distributor Drug Strength Packaging Formulation Formulation Strength Price
Nitrofurantoin Biodeal Laboratories Ltd. Biodeal Laboratories Ltd. 100mg 1000 Tablet per tablet KES 300.00
Nitrofurantoin Cosmos Limited. Cosmos Limited 100mg 100 Tablet per tablet KES 240.00
Nitrofurantoin Dawa Limited Dawa Limited 100mg 1000 Tablet per tablet KES 350.00
Nifuran Laboratory & Allied Ltd. Laboratory & Allied Ltd 100mg 100 Tablet per tablet KES 100.00
Nifuran Laboratory & Allied Ltd. Laboratory & Allied Ltd 100mg 1000 Tablet per tablet KES 500.00
Nitrofurantoin Pharmaceuticals Manufacturing Co. k Ltd. Pharmaceutical Manufacturing Co.(K) Ltd 100mg 1000 Tablet per tablet KES 550.00

Nitrofurantoin more info

Mode Of Action

Nitrofurans interfere with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A.
Drug Indication Urinary tract infection
Precautions Anaemia; diabetes mellitus; elect-rolyte imbalance; vitamin B and folate defic-iency; pulmonary disease; on long-term therapy, monitor liver function and monitor for pulmonary symptoms, especially in the elderly (discontinue if deterioration in lung function); susceptibility to peripheral neuropathy; false positive urinary glucose (if tested for reducing substances); urine may be coloured yellow or brown. Discontinue if paresthesia or haemolysis develops.
Contra-Indications Renal disorders, pregnancy and lactation, porphyria.
Side Effects GI disturbances, acute and chronic pulmonary reactions, peripheral neuropathy, lupus erythromatosus-like syndrome. Urticaria, rashes and pruritus.
Dosage Acute uncomplicated infection, 50mg every 6 hours with food for 7 days (3 days usually adequate in women); child over 3 months, 3mg/kg daily in 4 divided doses.Severe chronic recurrent infection, 100mg every 6 hours with food for 7 days (dose reduced or discontinued if severe nausea).Prophylaxis, 50-100mg at night; child over 3 months, 1mg/kg at night.
Pregnancy Category Category B:
Pregnancy Category Description Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Categorized further into:
Drug Category DRUGS ACTING ON INFECTIONS
Drug Sub-Category Other Antibiotics

Dosing: Adult

UTI treatment:

FuradantinŽ, MacrodantinŽ: Oral: 50-100 mg/dose every 6 hours; administer for 7 days or at least 3 days after obtaining sterile urine

MacrobidŽ: Oral: 100 mg twice daily for 7 days

UTI prophylaxis (FuradantinŽ, MacrodantinŽ): Oral: 50-100 mg/dose at bedtime

Dosing: Pediatric

(For additional information see "Nitrofurantoin: Pediatric drug information")

UTI treatment:

Children >1 month (FuradantinŽ, MacrodantinŽ): Oral: 5-7 mg/kg/day in divided doses every 6 hours (maximum: 400 mg/day). Administer for 7 days or at least 3 days after obtaining sterile urine.

Children >12 years (MacrobidŽ): Oral: Refer to adult dosing.

UTI prophylaxis: Children >1 month (FuradantinŽ, MacrodantinŽ): Oral: 1-2 mg/kg/day in divided doses every 12-24 hours (maximum: 100 mg/day)

Dosing: Geriatric

Refer to adult dosing