Dosage;
200mg on first day, then 100mg daily;
severe infections (including refractory urinary-tract infections), 200mg daily.
Early syphilis, 100mg twice daily for 14 days; late latent syphilis, 100mg twice daily for 28 days;
neurosyphilis, 200mg twice daily for 28 days.
Uncomplicated genital chlamydia, non-gonococcal urethritis, 100mg twice daily for 7 days (14 days in pelvic inflammatory disease).
Lyme disease, 100mg twice daily for 10-14 days (28 days in Lyme arthritis). Anthrax, 100mg twice daily;
child (only if alternative antibacterial cannot be given) 5mg/kg daily in 2 divided doses. (max. 200mg daily)
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Biodox | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 100mg | 1000 | Capsule | per capsule | KES 1,400.00 |
| Biodox | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 100mg | 100 | Capsule | per capsule | KES 150.00 |
| Caredoxy | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 100mg | 100 | Capsule | per capsule | KES 135.00 |
| Dawadoxyn | Dawa Limited | Dawa Limited | 100mg | 100 | Capsule | per capsule | KES 160.00 |
| Dawadoxyn | Dawa Limited | Dawa Limited | 100mg | 1000 | Capsule | per capsule | KES 1,000.00 |
| Doxan | Medivet Products Ltd | Medivet Products Ltd. | 100mg | 100 | Capsule | per capsule | KES POR |
| Doxy-100 | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 100mg | 100 | Capsule | per capsule | KES 2,261.00 |
| Doxy-100 | Universal Pharmaceuticals Ltd. | Universal Corporation Ltd | 100mg | 100 | Tablet | per tablet | KES 2,261.00 |
| Doxy | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 100mg | 100 | Capsule | per capsule | KES 160.00 |
| Doxy | Laboratory & Allied Ltd. | Laboratory & Allied Ltd | 100mg | 1000 | Capsule | per capsule | KES 1,300.00 |
| Doxycycline | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 100mg | 100 | Capsule | per capsule | KES 175.00 |
| Doxycycline | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 100mg | 1000 | Capsule | per capsule | KES 1,540.00 |
| Doxylin | Cosmos Limited. | Cosmos Limited | 100mg | 100 | Capsule | per capsule | KES 480.00 |
| Doxymax | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 100mg | 100 | Capsule | per capsule | KES 144.00 |
| Doxymed | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 100mg | 100 | Capsule | per capsule | KES 154.00 |
| Microdox | Micro - Labs Limited | Pharma Specialities Ltd. | 100mg | 100 | Capsule | per capsule | KES 168.00 |
| Biotet | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 250mg | 1000 | Capsule | per capsule | KES 1,500.00 |
| Mode Of Action | irreversibly binds to 30s sub-unit of bacterial ribosomes; blocks recognition step in protein synthesis and causes growth inhibition. |
|---|---|
| Drug Indication | Infections caused by chlamydia (trachoma, psittacosis, salpingitis, urethritis, and lymphogranuloma venereum), rickettsia (including Q-fever), brucella (doxycycline with either streptomycin or rifampicin), and the spirochaete, Borrelia burgdorferi (Lyme disease). Respiratory and genital mycoplasma infections, in acne, destructive (refractory) periodontal disease, exacerbations of chronic bronchitis (because of their activity against Haemophilus influenzae), and for leptospirosis in penicillin hy |
| Precautions | Renal and hepatic impairment, increased risk of nephrotoxicity if given with potent nephrotoxic drug. May aggravate myasthenia gravis symptoms. |
| Contra-Indications | Pregnancy and lactation, children under 12 years, SLE, co-administration with hepatotoxic drugs. |
| Side Effects | GI disturbances, super-infections, tooth discolouration and interference with bone development in children below 12 years. Renal and hepatic disturbances, photosensitivity, negative nitrogen balance in elderly, increase intra-ocular pressure, Jarisch-Herxheimer-like reaction, nail discolouration. |
| Dosage | 200mg on first day, then 100mg daily; severe infections (including refractory urinary-tract infections), 200mg daily. Early syphilis, 100mg twice daily for 14 days; late latent syphilis, 100mg twice daily for 28 days; neurosyphilis, 200mg twice daily for 28 days.Uncomplicated genital chlamydia, non-gonococcal urethritis, 100mg twice daily for 7 days (14 days in pelvic inflammatory disease).Lyme disease, 100mg twice daily for 10-14 days (28 days in Lyme arthritis). Anthrax, 100mg twice daily; child (only if alternative antibacterial cannot be given) 5mg/kg daily in 2 divided doses. (max. 200mg daily) |
| Special Information | Counselling: Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Tetracyclines |