Dosage;
Adult dose: Orally, 200mg daily in divided doses, every 12 hours;
an initial loading dose of 200mg may be given.
An oral dose of 50mg twice daily or 100mg once daily is used for the treatment of acne;
alternatively, a dose of about 1mg/kg once daily is also given as a modified-release preparation
to patients weighing 45kg and over. In asymptomatic meningococcal carriers,
100mg has been given orally twice daily for 5 days, usually followed by a course of rifampicin.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Minocycline | Cox Pharmaceuticals | 50mg | 28s | caps | per cap | KES 800.00 | |
Minocycline more info
| Mode Of Action | irreversibly binds to 30s sub-unit of bacterial ribosomes; blocks recognition step in protein synthesis and causes growth inhibition. |
|---|---|
| Drug Indication | Infections caused by chlamydia (trachoma, psittacosis, salpingitis, urethritis, and lymphogranuloma venereum), rickettsia (including Q-fever), brucella (doxycycline with either streptomycin or rifampicin), and the spirochaete, Borrelia burgdorferi (Lyme disease). Respiratory and genital mycoplasma infections, in acne, destructive (refractory) periodontal disease, exacerbations of chronic bronchitis (because of their activity against Haemophilus influenzae), and for leptospirosis in penicillin hy |
| Precautions | Renal and hepatic impairment, increased risk of nephrotoxicity if given with potent nephrotoxic drug. May aggravate myasthenia gravis symptoms.Increased risk of lupus-erythematosus-like syndrome and sometimes causes irreversible pigmentation. |
| Contra-Indications | Pregnancy and lactation, children under 12 years, SLE, co-administration with hepatotoxic drugs. |
| Side Effects | GI disturbances, super-infections, tooth discolouration and interference with bone development in children below 12 years. Renal and hepatic disturbances, photosensitivity, negative nitrogen balance in elderly, increase intra-ocular pressure, Jarisch-Herxheimer-like reaction, nail discolouration. |
| Dosage | Adult dose: Orally, 200mg daily in divided doses, every 12 hours; an initial loading dose of 200mg may be given. An oral dose of 50mg twice daily or 100mg once daily is used for the treatment of acne; alternatively, a dose of about 1mg/kg once daily is also given as a modified-release preparation to patients weighing 45kg and over. In asymptomatic meningococcal carriers, 100mg has been given orally twice daily for 5 days, usually followed by a course of rifampicin. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Tetracyclines |