Drug List Home Antibacterial Sensitivity Chart

Streptomycin

Dosing: Adult

Brucellosis: I.M.: 1 g/day for 14-21 days (with doxycycline, 100 mg twice daily for 6 weeks)

Endocarditis: I.M.:

Enterococcal: 1 g every 12 hours for 2 weeks, 500 mg every 12 hours for 4 weeks in combination with penicillin

Streptococcal: 1 g every 12 hours for 1 week

Mycobacterium avium complex: I.M.: Adjunct therapy (with macrolide, rifamycin, and ethambutol): 15 mg/kg 3 times/week for first 2-3 months for severe disease

Plague: I.M.: 15 mg/kg (or 1 g) every 12 hours until the patient is afebrile for at least 3 days

Tuberculosis: I.M.:

Daily therapy: 15 mg/kg/day (maximum: 1 g)

Directly observed therapy (DOT), twice weekly: 25-30 mg/kg (maximum: 1.5 g)

Directly observed therapy (DOT), 3 times/week: 25-30 mg/kg (maximum: 1.5 g)

Tularemia: I.M.: 10-15 mg/kg every 12 hours (maximum: 2 g/day) for 7-10 days or until patient is afebrile for 5-7 days

Dosing: Pediatric

(For additional information see "Streptomycin: Pediatric drug information")

Tuberculosis: I.M.:

Daily therapy: 20-40 mg/kg/day (maximum: 1 g/day)

Directly observed therapy (DOT), twice weekly: 25-30 mg/kg (maximum: 1.5 g)

Directly observed therapy DOT, 3 times/week: 25-30 mg/kg (maximum: 1.5 g)

Dosing: Geriatric

I.M.: 10 mg/kg/day, not to exceed 750 mg/day; dosing interval should be adjusted for renal function. Some authors suggest not to give more than 5 days/week or give as 20-25 mg/kg/dose twice weekly.

Dosing: Renal Impairment

Clcr 10-50 mL/minute: Administer every 24-72 hours.

Clcr <10 mL/minute: Administer every 72-96 hours.

Removed by hemo- and peritoneal dialysis: Administer dose postdialysis