Dosage;
Usual dose is 2 to 4g daily in 2 divided doses.
In severe infections, up to 12g daily in 2 to 4 divided doses may be given.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Bactacef | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 500mg/500mg | 1 | Injection | per vial | KES 450.00 |
| Cebanex | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 500mg/500mg | 1 | Injection | per vial | KES 780.00 |
| Cesalac | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 500mg/500mg | 1 | Injection | per vial | KES 194.00 |
| Cefoperazone / Sulbactam | |
|---|---|
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
| Drug Indication | Susceptible infections, especially those due to pseudomonas species. |
| Precautions | Potential for colonisation and superinfection with resistant organisms. Changes in bowel flora may be more marked than with cefotaxime because of the greater biliary excretion of cefoperazone; diarrhoea may occur more often. Cefoperazone contains an N-methylthiotetrazole side-chain, a structure associated with hypoprothrombinaemia. Hypoprothrombinaemia has been reported in patients treated with cefoperazone and has rarely been associated with bleeding episodes. Prothrombin time should be monitored in patients at risk of hypoprothrombinaemia and vitamin K used if necessary. |
| Contra-Indications | Cephalosporin allergy. |
| Side Effects | Diarrhoea and rarely antibiotic-associated colitis, nausea and vomiting, abdominal discomfort, headache; allergic reactions including rashes, pruritus, urticaria, serum sickness-like reactions with rashes, fever and arthralgia, and anaphylaxis; Stevens-Johnson syndrome, toxic epidermal necrolysis reported; disturbances in liver enzymes, transient hepatitis and cholestatic jaundice; other side-effects reported include eosinophilia and blood disorders (including thrombocytopenia, leucopenia, agran |
| Dosage | Usual dose is 2 to 4g daily in 2 divided doses. In severe infections, up to 12g daily in 2 to 4 divided doses may be given. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |