Dosage;
Usual dose is the equivalent of 0.25 to 1g of cefazolin every 6, 8, or 12 hours.
In severe, life-threatening infections 1 to 1.5g every 6 hours may be given;
up to 12g daily has been used
. For the prophylaxis of infection during surgery, a 1g dose is given half to one hour before the operation,
followed by 0.5 to 1g during surgery for lengthy procedures.
A dose of 0.5 to 1g is given every 6 to 8 hours postoperatively for 24 hours or up to 5 days in certain cases.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Fazilin | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 1000mg | 1 | Injection | per vial | KES 200.00 |
| Kefzol | Eli Lilly & Co. | Statim Pharmaceuticals Ltd | 1000mg | 1 | Injection | per vial | KES 505.90 |
| Linzec | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 1000mg | 1 | Injection | per vial | KES 220.00 |
| Orizolin | Zydus Cadila Healthcare | Harley's Limited | 1000mg | 1 | Injection | per vial | KES 137.00 |
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
|---|---|
| Drug Indication | Susceptible RTI, UTI, skin and soft tissue, post-operative infections. |
| Precautions | Renal impairment, lactating mothers. |
| Contra-Indications | Allergy to cephalosporins. |
| Side Effects | Moniliasis, super-infections, allergic reactions, pseudomembranous colitis, blood dyscrasia, cholestatic jaundice. |
| Dosage | Usual dose is the equivalent of 0.25 to 1g of cefazolin every 6, 8, or 12 hours. In severe, life-threatening infections 1 to 1.5g every 6 hours may be given; up to 12g daily has been used. For the prophylaxis of infection during surgery, a 1g dose is given half to one hour before the operation, followed by 0.5 to 1g during surgery for lengthy procedures. A dose of 0.5 to 1g is given every 6 to 8 hours postoperatively for 24 hours or up to 5 days in certain cases. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |