Dosage;
I.M or I.V injection or infusion, 1g every 12hours increased in severe infections
(e.g. meningitis) to 8g daily in 4 divided doses;
higher doses (up to 12g daily in 3-4 divided doses) may be required;
neonate 50mg/kg daily in 2-4 divided doses increased to 150-200 mg/kg daily in severe infections;
child 100-150 mg/kg daily in 2-4 divided doses increased up to 200mg/kg daily in very severe infections.
Gonorrhoea, 500 mg as a single dose.
Combinations Cefotaxime / Sulbactum -See below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Cefotax | E.I.P.C.O. | Zadchem Pharmacy Ltd. | 500mg | 1 | Injection | per vial | KES 320.00 |
| Evacef | Neon Laboratories Ltd | Sai Pharmaceuticals Ltd. | 500mg | 1 | Injection | per vial | KES 66.00 |
| Evacef | Neon Laboratories Ltd | Sai Pharmaceuticals Ltd. | 1g | 1 | Injection | per vial | KES 88.00 |
| Maxcef | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 1g | 1 | Injection | per vial | KES 350.00 |
| Oritaxim | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 250mg | 1 | Injection | per vial | KES 180.00 |
| Oritaxim | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 500mg | 1 | Injection | per vial | KES 350.00 |
| Oritaxim | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 1000mg | 1 | Injection | per vial | KES 720.00 |
| Tax-o-Bid | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 1g | 1 | Injection | per vial | KES 300.00 |
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
|---|---|
| Drug Indication | Septicaemia, meningitis in neonates and infants, peri-operative infections prophylaxis, UTI, RTI, bone, joints, skin and soft tissue infections. |
| Precautions | Penicillin /cephalosporin sensitivity, pregnacy, impaired renal functions. |
| Contra-Indications | Hypersensitivity reaction, penicillin cross-sensitivity. |
| Side Effects | GI disturbances, allergic reactions, blood dyscrasia, severe headaches, glossitis, pain at I.M injection site, pseudomembranous entero-colitis, oedema, genital tract mycosis, oliguria. |
| Dosage | By I.M or I.V injection or infusion, 1g every 12hours increased in severe infections (e.g. meningitis) to 8g daily in 4 divided doses; higher doses (up to 12g daily in 3-4 divided doses) may be required; neonate 50mg/kg daily in 2-4 divided doses increased to 150-200 mg/kg daily in severe infections; child 100-150 mg/kg daily in 2-4 divided doses increased up to 200mg/kg daily in very severe infections.Gonorrhoea, 500 mg as a single dose. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |
| Cefotaxime / Sulbactum | |
|---|---|
| Mode Of Action | interfere with the synthesis of peptidoglycans, which are part of bacterial cell wall (bactericidal). Sulbactam is a beta-lactamase inhibitor |
| Drug Indication | Septicaemia, meningitis in neonates and infants, peri-operative infections prophylaxis, UTI, RTI, bone, joints, skin and soft tissue infections. |
| Precautions | Penicillin /cephalosporin sensitivity, pregnacy, impaired renal functions. |
| Contra-Indications | Hypersensitivity reaction, penicillin cross-sensitivity. |
| Side Effects | GI disturbances, allergic reactions, blood dyscrasia, severe headaches, glossitis, pain at I.M injection site, pseudomembranous entero-colitis, oedema, genital tract mycosis, oliguria. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |
Cefotaxime / Sulbactum Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Zetex | Kilitch Pharmaceuticals Ltd | 500mg/500mg | 1 | Injection | per vial | KES 600.00 | |