Dosage;
URTIs (but in pharyngitis and tonsillitis reserved for infections which are recurrent,
chronic, or resistant to other antibacterials), 100mg twice daily (200mg twice daily in sinusitis);
Child 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours,
Over 9 years 100mg every 12 hours. LRTIs (including bronchitis and pneumonia), 100-200mg twice daily;
Child 15 days-6 months 4mg/kg every 12 hours,
6 months-2 years 40mg every 12 hours,
3-8 years 80mg every 12 hours, over 9 years 100mg every 12 hours.
Skin and soft-tissue infections, 200mg twice daily; C
hild 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours,
3-8 years 80mg every 12 hours,
over 9 years 100mg every 12 hours.
Uncomplicated urinary-tract infections, 100mg twice daily
(200mg twice daily in uncomplicated upper urinary-tract infections);
child 15 days-6 months 4mg/kg every 12 hours,
6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours,
over 9 years 100mg every 12 hours. Uncomplicated gonorrhoea, 200mg as a single dose.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Auropodox | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 200mg | 10 | Tablet | per tablet | KES 710.00 |
| Auropodox | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 100mg | 10 | Tablet | per tablet | KES 325.00 |
| Cepom | Questa Care Inc. | Simba Pharmaceutical Ltd. | 200mg | 10 | Tablet | per tablet | KES 600.00 |
| Cefaz | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 200mg | 10 | Tablet | per tablet | KES 650.00 |
| Cefaz | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 50mg | 60ml | Suspension | per 5ML | KES 350.00 |
| Cefwar | Leben Laboratories PVT Limited | Unisel Pharma (K) Ltd. | 200mg | 100 | Tablet | per tablet | KES 4,000.00 |
| Cepotil | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 100mg | 20 | Tablet | per tablet | KES 860.00 |
| Cepotil | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 200mg | 20 | Tablet | per tablet | KES 1,600.00 |
| Monocef-O | Aristo Pharmaceuticals Ltd. | British Pharmaceuticals Ltd | 200mg | 10 | Tablet | per tablet | KES 1,200.00 |
| Monocef-O | Aristo Pharmaceuticals Ltd. | British Pharmaceuticals Ltd | 100mg | 60ml | Dry Syrup | per 5ML | KES 786.00 |
| Orelox | Sanofi Aventis | Surgipharm Ltd | 100mg | 10 | Tablet | per tablet | KES 1,272.00 |
| Orelox | Sanofi Aventis | Surgipharm Ltd | 200mg | 10 | Tablet | per tablet | KES 1,450.00 |
| Orelox | Sanofi Aventis | Surgipharm Ltd | 400mg | 50ml | Suspension | per 5ML | KES 1,170.00 |
| Orelox | Sanofi Aventis | Surgipharm Ltd | 800mg | 100ml | Suspension | per 5ML | KES 1,761.00 |
| Oxipod | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 100mg | 10 | Tablet | per tablet | KES 408.00 |
| Oxipod | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 200mg | 10 | Tablet | per tablet | KES 612.00 |
| Oxipod | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 50mg | 60ml | Suspension | per 5ML | KES 510.00 |
| Oxipod | Indoco Remedies Ltd. | Sai Pharmaceuticals Ltd. | 40mg | 30ml | Dry Syrup | per 5ML | KES 306.00 |
| Poxil | Bharat Biotech International Ltd | Nairobi Enterprises Limited | 100mg | 10 | Tablet | per tablet | KES 360.00 |
| Poxil | Bharat Biotech International Ltd | Nairobi Enterprises Limited | 200mg | 10 | Tablet | per tablet | KES 480.00 |
| Poxil | Bharat Biotech International Ltd | Nairobi Enterprises Limited | 100mg | 60ml | Suspension | per 5ML | KES 440.00 |
| Tambac | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 50mg | 60ml | Suspension | per 5ML | KES 410.00 |
| Vanprox | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 200mg | 6 | Tablet | per tablet | KES 206.00 |
| Ximeprox | Incepta Pharma | Radiance Pharmaceuticals Limited | 40mg | 50ml | Suspension | per 5ML | KES 470.00 |
| Ximeprox | Incepta Pharma | Radiance Pharmaceuticals Limited | 40mg | 100ml | Suspension | per 5ML | KES 790.00 |
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
|---|---|
| Drug Indication | Infections due to sensitive Gram-positive and Gram-negative bacteria. |
| Precautions | Impaired renal function, penicillin cross sensitivity. |
| Contra-Indications | Sensitivity to cephalosporins. |
| Side Effects | Diarrhoea and rarely antibiotic-associated colitis, nausea and vomiting, abdominal discomfort, headache; allergic reactions including rashes, pruritus, urticaria, serum sickness-like reactions with rashes, fever and arthralgia, and anaphylaxis; Stevens-Johnson syndrome, toxic epidermal necrolysis reported; disturbances in liver enzymes, transient hepatitis and cholestatic jaundice; other side-effects reported include eosinophilia and blood disorders (including thrombocytopenia, leucopenia, agran |
| Dosage | URTIs (but in pharyngitis and tonsillitis reserved for infections which are recurrent, chronic, or resistant to other antibacterials), 100mg twice daily (200mg twice daily in sinusitis); child 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours, over 9 years 100mg every 12 hours. LRTIs (including bronchitis and pneumonia), 100-200mg twice daily; child 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours, over 9 years 100mg every 12 hours. Skin and soft-tissue infections, 200mg twice daily; child 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours, over 9 years 100mg every 12 hours. Uncomplicated urinary-tract infections, 100mg twice daily (200mg twice daily in uncomplicated upper urinary-tract infections); child 15 days-6 months 4mg/kg every 12 hours, 6 months-2 years 40mg every 12 hours, 3-8 years 80mg every 12 hours, over 9 years 100mg every 12 hours. Uncomplicated gonorrhoea, 200mg as a single dose. |
| Special Information | A third generation oral cephalosporin. |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |