Dosage;
Adult dose, 500mg daily (as a single dose or in two divided doses),
increased to 500mg twice daily if necessary.
Children 6 months onwards, oral doses of 15 mg/kg every 12 hours for the treatment of otitis media,
7.5 or 15mg/kg every 12 hours for acute sinusitis and 7.5mg/kg every 12 hours for pharyngitis or tonsillitis.
Children from the age of 2 years may be given 20 mg/kg once daily for skin and skin structure infections.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Aurozil | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 125mg | 60ml | Syrup | per 5ML | KES 660.00 |
| Aurozil | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 250mg | 60ml | Syrup | per 5ML | KES 1,170.00 |
| Cefzil | Bristol | 250mg | 10s | Tablet | per tablet | KES 2500.00 |
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
|---|---|
| Drug Indication | Respiratory tract infections, otitis media, skin and tissues infections and other infections caused by susceptible micro-organisms. |
| Precautions | Impaired renal function, penicillin cross sensitivity. |
| Contra-Indications | Sensitivity to cephalosporins. |
| Side Effects | GI disturbances, vaginal moniliasis and vaginitis, allergic reactions, increase prothrombin time, super-infections, hepatic dysfunctions, Stevens-Johnson syndrome, erythema multiforme, fever, CNS effects. |
| Dosage | Adult dose, 500mg daily (as a single dose or in two divided doses), increased to 500mg twice daily if necessary. Children 6 months onwards, oral doses of 15 mg/kg every 12 hours for the treatment of otitis media, 7.5 or 15mg/kg every 12 hours for acute sinusitis and 7.5mg/kg every 12 hours for pharyngitis or tonsillitis. Children from the age of 2 years may be given 20 mg/kg once daily for skin and skin structure infections. |
| Special Information | A second generation cephalosporin whose activity is comparable to cefaclor |
| Pregnancy Category | Category B1 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals have not shown evidence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |