Dosage;
By mouth (as cefuroxime axetil), 250mg twice daily in most infections
including mild to moderate lower respiratory-tract infections (e.g. bronchitis);
doubled for more severe lower respiratory-tract infections or if pneumonia suspected.
Urinary-tract infection, 125mg twice daily, doubled in pyelonephritis. Gonorrhoea, 1g as a single dose.
Child over 3 months, 125mg twice daily, if necessary doubled in child over 2 years with otitis media.
Lyme disease, adult and child over 12 years, 500mg twice daily for 14-21 days
(for 28 days in Lyme arthritis) [unlicensed duration].
By I.M injection or I.V injection or infusion, 750mg every 6-8 hours;
1.5g every 6-8 hours in severe infections; single doses over 750mg I.V route only.
Child usual dose 60 mg/kg daily (range 30-100mg/kg daily) in 3-4 divided doses
(2-3 divided doses in neonates).
Gonorrhoea, 1.5g as a single dose by intramuscular injection (divided between 2 sites).
Surgical prophylaxis, 1.5g by intravenous injection at induction;
up to 3 further doses of 750mg may be given by intramuscular or intravenous injection
every 8 hours for high-risk procedures. Meningitis, 3g intravenously every 8 hours; C
hild, 200-240 mg/kg daily (in 3-4 divided doses) reduced to 100 mg/kg daily after 3 days
or on clinical improvement; neonate, 100mg/kg daily reduced to 50mg/kg daily.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Altacef | Glenmark | Galaxy Pharmaceuticals Ltd | 250mg | 10 | Tablet | per tablet | KES 442.00 |
| Altacef | Glenmark | Galaxy Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 900.00 |
| Altacef | Glenmark | Galaxy Pharmaceuticals Ltd | 125mg | 50ml | Suspension | per 5ML | KES 394.00 |
| Axacef | Sanofi Aventis | Surgipharm Ltd | 250mg | 10 | Tablet | per tablet | KES 415.00 |
| Axacef | Sanofi Aventis | Surgipharm Ltd | 250mg | 14 | Tablet | per tablet | KES 493.00 |
| Axacef | Sanofi Aventis | Surgipharm Ltd | 500mg | 10 | Tablet | per tablet | KES 800.00 |
| Axacef | Sanofi Aventis | Surgipharm Ltd | 500mg | 14 | Tablet | per tablet | KES 750.00 |
| Bcef | Bharat Biotech International Ltd | Pharma Specialities Ltd. | 250mg | 10 | Tablet | per tablet | KES 480.00 |
| Bcef | Bharat Biotech International Ltd | Pharma Specialities Ltd. | 500mg | 10 | Tablet | per tablet | KES 600.00 |
| Bcef | Bharat Biotech International Ltd | Pharma Specialities Ltd. | 125mg | 50ml | Suspension | per 5ML | KES 260.00 |
| Cefact | Cipla Ltd. | Surgipharm Ltd | 500mg | 10 | Tablet | per tablet | KES 1,063.00 |
| Cefact | Cipla Ltd. | Surgipharm Ltd | 750mg | 15ml | Injection | per vial | KES 402.00 |
| Cefakind | Mankind Pharma Limited | Pharma Specialities Ltd. | 500mg | 10 | Tablet | per tablet | KES 530.00 |
| Cefasyn | Cipla Ltd. | Surgipharm Ltd | 500mg | 10 | Tablet | per tablet | KES 750.00 |
| Cefasyn | Cipla Ltd. | Surgipharm Ltd | 750mg | 15ml | Injection | per vial | KES 380.00 |
| Cefeal | Questa Care Inc. | Simba Pharmaceutical Ltd. | 125mg | 50ml | Suspension | per 5ML | KES 450.00 |
| Cefogen | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 750mg | 1 | Injection | per vial | KES 310.00 |
| Cefotil | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 250mg | 20 | Tablet | per tablet | KES 750.00 |
| Cefotil | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 650.00 |
| Cefotil | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 125mg | 70ml | Suspension | per 5ML | KES 380.00 |
| Cefotil | Square Pharmaceuticals Ltd | ACE Pharmaceuticals Ltd | 750mg | 1 | Injection | per vial | KES 300.00 |
| Cefoxim | Biochem | Sai Pharmaceuticals Ltd. | 250mg | 10 | Tablet | per tablet | KES 510.00 |
| Cefoxim | Biochem | Sai Pharmaceuticals Ltd. | 500mg | 10 | Tablet | per tablet | KES 765.00 |
| Cefoxim | Biochem | Sai Pharmaceuticals Ltd. | 750mg | 1 | Injection | per vial | KES 263.00 |
| Ceftyl | Dafra Phama | Harley's Limited | 500mg | 10 | Tablet | per tablet | KES 1,015.00 |
| Cefuken | Sance Laboratories Ltd | Pharmaken Ltd | 500mg | 10 | Tablet | per tablet | KES 1,125.00 |
| Cefuken | Sance Laboratories Ltd | Pharmaken Ltd | 125mg | 50ml | Suspension | per 5ML | KES 565.00 |
| Cefuxime | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 250mg | 10 | Tablet | per tablet | KES 350.00 |
| Cefuxime | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 500mg | 10 | Tablet | per tablet | KES 520.00 |
| Cefuxime | Aurobindo Pharma Ltd. | Simba Pharmaceutical Ltd. | 750mg | 1 | Injection | per vial | KES 230.00 |
| Cefuzime | Gulf Pharmaceuticals (See also Julphar) | Goodman Agencies Ltd | 250mg | 10 | Tablet | per tablet | KES 800.00 |
| Cefuzime | Gulf Pharmaceuticals (See also Julphar) | Goodman Agencies Ltd | 500mg | 10 | Tablet | per tablet | KES 1,250.00 |
| Cefuzime | Gulf Pharmaceuticals (See also Julphar) | Goodman Agencies Ltd | 125mg | 50ml | Suspension | per 5ML | KES 700.00 |
| Celzar | Cachet Pharmaceuticals PVT Ltd | Galaxy Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 550.00 |
| Celzar | Cachet Pharmaceuticals PVT Ltd | Galaxy Pharmaceuticals Ltd | 750mg | 15ml | Injection | per vial | KES 402.00 |
| Celzar | Cachet Pharmaceuticals PVT Ltd | Galaxy Pharmaceuticals Ltd | 150mg | 50ml | Syrup | per 5ML | KES 350.00 |
| C-tri T | Emcure Pharmaceuticals Limited | Syner-Medica (K) Ltd | 250mg | 10 | Tablet | per tablet | KES 300.00 |
| C-tri T | Emcure Pharmaceuticals Limited | Syner-Medica (K) Ltd | 500mg | 10 | Tablet | per tablet | KES 330.00 |
| Evorox | Pharmevo Pharmaceuticals Ltd | Harley's Limited | 750mg | 1 | Injection | per vial | KES 319.00 |
| Evorox | Pharmevo Pharmaceuticals Ltd | Harley's Limited | 125mg | 50ml | Suspension | per 5ML | KES 479.00 |
| Forcef | Aristo Pharmaceuticals Ltd. | British Pharmaceuticals Ltd | 250mg | 40 | Tablet | per tablet | KES 1,600.00 |
| Forcef | Aristo Pharmaceuticals Ltd. | British Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 550.00 |
| Forcef | Aristo Pharmaceuticals Ltd. | British Pharmaceuticals Ltd | 750mg | 1 | Injection | per vial | KES 360.00 |
| Furocef | Renata Limited | Unisel Pharma (K) Ltd. | 250mg | 16 | Tablet | per tablet | KES 390.00 |
| Furocef | Renata Limited | Unisel Pharma (K) Ltd. | 500mg | 12 | Tablet | per tablet | KES 450.00 |
| Furotil | Healthcare Pharmaceuticals | Crown Healthcare | 250mg | 10 | Tablet | per tablet | KES 365.00 |
| Furotil | Healthcare Pharmaceuticals | Crown Healthcare | 500mg | 10 | Tablet | per tablet | KES 640.00 |
| Infrid | Medicraft Pharmaceuticals Ltd | Kulal International Ltd. | 750mg | 1 | Injection | per vial | KES 148.00 |
| Kefax | Prisma Pharmaceuticals Ltd. | Galaxy Pharmaceuticals Ltd | 250mg | 10 | Tablet | per tablet | KES 510.00 |
| Kefax | Prisma Pharmaceuticals Ltd. | Galaxy Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 850.00 |
| Kefstar | Wockhardt International | Pharma Specialities Ltd. | 250mg | 10 | Tablet | per tablet | KES 494.00 |
| Kefstar | Wockhardt International | Pharma Specialities Ltd. | 500mg | 10 | Tablet | per tablet | KES 790.00 |
| Kefstar | Wockhardt International | Pharma Specialities Ltd. | 125mg | 50ml | Suspension | per 5ML | KES 482.00 |
| Kefstar | Wockhardt International | Pharma Specialities Ltd. | 750mg | 1 | Injection | per vial | KES 248.00 |
| Kefrox | CCL Pharma | Harley's Limited | 500mg | 10 | Tablet | per tablet | KES 778.00 |
| Kefrox | CCL Pharma | Harley's Limited | 125mg | 50ml | Suspension | per 5ML | KES 449.00 |
| Kefrox | CCL Pharma | Harley's Limited | 250mg | 50ml | Suspension | per 5ML | KES 603.00 |
| Kefrox | CCL Pharma | Harley's Limited | 750mg | 1 | Injection | per vial | KES 200.00 |
| Kefurox | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 250mg | 10 | Tablet | per tablet | KES 160.00 |
| Kefurox | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 500mg | 10 | Tablet | per tablet | KES 525.00 |
| Kefurox | Flamingo Pharmaceuticals Ltd. | Harley's Limited | 750mg | 1 | Injection | per vial | KES 90.00 |
| Kilbac | Incepta Pharma | Radiance Pharmaceuticals Limited | 125mg | 70ml | Suspension | per 5ML | KES 400.00 |
| Medcefur | Comed Chemicals | Europa Healthcare Ltd. | 250mg | 10 | Tablet | per tablet | KES 645.00 |
| Medcefur | Comed Chemicals | Europa Healthcare Ltd. | 500mg | 10 | Tablet | per tablet | KES 1,105.00 |
| Milcef | Comed Chemicals | Europa Healthcare Ltd. | 250mg | 10 | Tablet | per tablet | KES 890.00 |
| Milcef | Comed Chemicals | Europa Healthcare Ltd. | 500mg | 10 | Tablet | per tablet | KES 960.00 |
| Proximexa | GlaxoSmithkline | GlaxoSmithKline | 250mg | 10 | Tablet | per tablet | KES 816.80 |
| Proximexa | GlaxoSmithkline | GlaxoSmithKline | 500mg | 10 | Tablet | per tablet | KES 1,469.00 |
| Proximexa | GlaxoSmithkline | GlaxoSmithKline | 125mg | 50ml | Suspension | per 5ML | KES 567.60 |
| Proximexa | GlaxoSmithkline | GlaxoSmithKline | 250mg | 50ml | Suspension | per 5ML | KES 887.30 |
| Pulmocef | Micro - Labs Limited | Pharma Specialities Ltd. | 250mg | 10 | Tablet | per tablet | KES 371.00 |
| Pulmocef | Micro - Labs Limited | Pharma Specialities Ltd. | 500mg | 10 | Tablet | per tablet | KES 695.00 |
| Pulmocef | Micro - Labs Limited | Pharma Specialities Ltd. | 750mg | 1 | Injection | per vial | KES 333.95 |
| Roxicef | Sanofi Aventis | Laborex Kenya Eurapharma Ltd | 750mg | 1 | Injection | per vial | KES 316.00 |
| Roxicef | Sanofi Aventis | Laborex Kenya Eurapharma Ltd | 750mg | 10 | Injection | per vial | KES 1,871.00 |
| Rufex | Global Pharma Healthcare Pvt. Ltd | Medox Pharmaceuticals Ltd. | 250mg | 10 | Tablet | per tablet | KES 710.00 |
| Rufex | Global Pharma Healthcare Pvt. Ltd | Medox Pharmaceuticals Ltd. | 500mg | 10 | Tablet | per tablet | KES 1,215.00 |
| Rufex | Global Pharma Healthcare Pvt. Ltd | Medox Pharmaceuticals Ltd. | 125mg | 60ml | Suspension | per 5ML | KES 520.00 |
| Sanfurox | Bliss GVS Pharma Ltd (See also GVS) | Pan Pharmaceuticals Ltd | 750mg | 1 | Injection | per vial | KES 235.00 |
| Sefur | Opsonin Pharma | Radiance Pharmaceuticals Limited | 125mg | 70ml | Suspension | per 5ML | KES 470.00 |
| Sefur | Opsonin Pharma | Radiance Pharmaceuticals Limited | 750mg | 1 | Injection | per vial | KES 280.00 |
| Spizef | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 250mg | 10 | Tablet | per tablet | KES 625.00 |
| Spizef | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 500mg | 10 | Tablet | per tablet | KES 875.00 |
| Spizef | Orchid Healthcare | Sunpar Pharmaceuticals Ltd. | 750mg | 1 | Injection | per vial | KES 240.00 |
| Synercef | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 250mg | 10 | Tablet | per tablet | KES 300.00 |
| Synercef | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 500mg | 10 | Tablet | per tablet | KES 330.00 |
| Synercef | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 125mg | 50ml | Suspension | per 5ML | KES 340.00 |
| Synercef | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 125mg | 100ml | Suspension | per 5ML | KES 500.00 |
| Ximecor | Coral Laboratories Ltd | Signature Healthcare Limited | 500mg | 10 | Tablet | per tablet | KES 850.00 |
| Zifora | Biopharm Group | Maxim Pharmaceuticals Ltd | 250mg | 10 | Tablet | per tablet | KES 250.00 |
| Zifora | Biopharm Group | Maxim Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 300.00 |
| Zinacef | GlaxoSmithkline | GlaxoSmithKline | 750mg | 5 | Injection | per vial | KES 2,420.90 |
| Zinnat | GlaxoSmithkline | GlaxoSmithKline | 250mg | 10 | Tablet | per tablet | KES 1,139.90 |
| Zinnat | GlaxoSmithkline | GlaxoSmithKline | 500mg | 10 | Tablet | per tablet | KES 2,091.90 |
| Zinnat | GlaxoSmithkline | GlaxoSmithKline | 125mg | 50ml | Suspension | per 5ML | KES 698.10 |
| Zinnat | GlaxoSmithkline | GlaxoSmithKline | 125mg | 100ml | Suspension | per 5ML | KES 1,222.20 |
| Zinnat | GlaxoSmithkline | GlaxoSmithKline | 250mg | 50ml | Suspension | per 5ML | KES 1,222.20 |
| Zolidon | Cosmos Limited. | Cosmos Limited | 250mg | 10 | Tablet | per tablet | KES 600.00 |
| Zolidon | Cosmos Limited. | Cosmos Limited | 500mg | 10 | Tablet | per tablet | KES 810.00 |
| Zolidon | Cosmos Limited. | Cosmos Limited | 125mg | 50ml | Suspension | per 5ML | KES 420.00 |
| Zolidon | Cosmos Limited. | Cosmos Limited | 125mg | 70ml | Suspension | per 5ML | KES 450.00 |
| Zolidon | Cosmos Limited. | Cosmos Limited | 250mg | 50ml | Suspension | per 5ML | KES 600.00 |
| Mode Of Action | Inhibits synthesis of bacterial cell wall, causing cell death, hence bactericidal. required. |
|---|---|
| Drug Indication | Septicaemia, meningitis in neonates and infants, peri-operative infections prophylaxis, UTI, RTI, bone, joints, skin and soft tissue infections, N. gonorrhoea and H. influenza. |
| Precautions | Penicillin sensitivity, pregnancy, impaired renal function. |
| Contra-Indications | Hypersensitivity reactions, penicillin cross-sensitivity. |
| Side Effects | GI disturbances, allergic reactions, blood dyscrasia, severe headaches, glossitis, pain at I.M injection site, pseudomembranous colitis, oedema, genital tract mycosis and oliguria. |
| Dosage | Dose: By mouth (as cefuroxime axetil), 250mg twice daily in most infections including mild to moderate lower respiratory-tract infections (e.g. bronchitis); doubled for more severe lower respiratory-tract infections or if pneumonia suspected.Urinary-tract infection, 125mg twice daily, doubled in pyelonephritis. Gonorrhoea, 1g as a single dose. Child over 3 months, 125mg twice daily, if necessary doubled in child over 2 years with otitis media. Lyme disease, adult and child over 12 years, 500mg twice daily for 14-21 days (for 28 days in Lyme arthritis) [unlicensed duration]. By I.M injection or I.V injection or infusion, 750mg every 6-8 hours; 1.5g every 6-8 hours in severe infections; single doses over 750mg I.V route only.Child usual dose 60 mg/kg daily (range 30-100mg/kg daily) in 3-4 divided doses (2-3 divided doses in neonates). Gonorrhoea, 1.5g as a single dose by intramuscular injection (divided between 2 sites).Surgical prophylaxis, 1.5g by intravenous injection at induction; up to 3 further doses of 750mg may be given by intramuscular or intravenous injection every 8 hours for high-risk procedures. Meningitis, 3g intravenously every 8 hours; child, 200-240 mg/kg daily (in 3-4 divided doses) reduced to 100 mg/kg daily after 3 days or on clinical improvement; neonate, 100mg/kg daily reduced to 50mg/kg daily. |
| Pregnancy Category | Category B: |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Categorized further into: |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Cephalosporins |