Dose Adult
400 mg orally or IV once daily. Duration depends on infection (typically 5–14 days).
Dose Paeds
Not routinely recommended in children except under specialist advice.
Gatifloxacin Brands
| Brand | Manufacturer | Formulation | Availability |
|---|---|---|---|
| Tequin® | Bristol-Myers Squibb (historical) | Tablet/Injection | Historical |
| Zymar® | Allergan | 0.3% Eye Drops | International |
| Zymaxid® | Allergan | 0.5% Eye Drops | International |
| Gatiflox Eye Drops | Various manufacturers | 0.3% Ophthalmic | Limited availability |
| No currently verified PPB-registered systemic Gatifloxacin brands identified in Kenya. | |||
Combinations
No common fixed-dose combinations. Avoid concurrent antacids, iron and zinc around dosing time.
| Gatifloxacin More action | |
|---|---|
| Indications | Respiratory tract infections, urinary tract infections, bacterial conjunctivitis (ophthalmic preparations) and other susceptible infections. |
| Precautions | QT prolongation, dysglycaemia, renal impairment, elderly patients, tendon disorders and seizure history. |
| Contraindications | Hypersensitivity to quinolones; avoid systemic use in patients with significant glucose regulation disorders. |
| Pregnancy/Lactation | Avoid during pregnancy and breastfeeding unless benefits outweigh risks. |
| Adverse reaction | Nausea, diarrhoea, dizziness, headache, QT prolongation, hypo/hyperglycaemia, tendinitis and tendon rupture. |
| Polypharmacy | Warfarin, antidiabetic medicines, QT-prolonging drugs, NSAIDs, iron, zinc and antacids may interact. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Fluoroquinolone Antibiotics |