Drug List Home Antibacterial Sensitivity Chart

Cloxacillin

Adult dose

Susceptible infections:

Oral: 250-500 mg every 6 hours (manufacturer recommended maximum adult dose: 6 g/day)

I.M., I.V.: 250-500 mg every 6 hours (manufacturer recommended maximum adult dose: 6 g/day)

Dosing recommendations of World Health Organization unless otherwise noted:

Arthritis (septic), methicillin-sensitive Staphylococcus aureus (MSSA) (unlabeled dosing):

I.M., I.V.: 2 g every 6 hours for 2-3 weeks;

Note: Oral therapy of 1 g every 6 hours may be used to complete therapy

if parenteral therapy is discontinued prior to 2-3 week duration

Endocarditis (MSSA) (unlabeled dosing): I.V.:

Native valve: 2 g every 4 hours for 6 weeks; may give with gentamicin for initial 5 days (Choudri, 2000)

Prosthetic valve: 2 g every 4 hours for 6 weeks; give with gentamicin for

2 weeks and rifampin for 6 weeks (Choudri, 2000)

Uncomplicated endocarditis in I.V. drug users: 2 g every 4 hours for 4 weeks and

gentamicin for initial 5 days or 2 g every 4 hours and gentamicin both given for 2 weeks total (Choudri, 2000)

Osteomyelitis (MSSA) (unlabeled dosing): I.M., I.V.: 2 g every 6 hours for 4-6 weeks

(preferred) or for a minimum of 14 days, followed by 1 g every 6 hours orally to complete 4-6 weeks of therapy

Pneumonia (MSSA) (unlabeled dosing): I.M., I.V.: 1-2 g every 6 hours for 10-14 days

Dosing: Pediatric

Note: Dose and duration of therapy can vary depending on infecting organism,

severity of infection, and clinical response of patient. Treat severe staphylococcal infections for at least 14 days;

endocarditis and osteomyelitis require an extended duration of therapy for 4-6 weeks.

The intravenous route should be used for severe infections.

Susceptible infections:

Oral:

Children ≤20 kg: 25-50 mg/kg/day in divided doses every 6 hours

Children >20 kg: Refer to adult dosing.

I.M., I.V.:

Children ≤20 kg: 25-50 mg/kg/day in divided doses every 6 hours; up to 200 mg/kg/day

has been used in some studies for severe infections (Nunn, 2007; St. John, 1981)

Children >20 kg: Refer to adult dosing.

Dosing recommendations of World Health Organization unless otherwise noted:

Arthritis (septic), methicillin-sensitive Staphylococcus aureus (MSSA) (unlabeled dosing):

Children 2 months to 5 years: I.M., I.V.: 25-50 mg/kg (maximum: 2 g)

every 4-6 hours given with ceftriaxone until clinical improvement, followed by oral therapy:

12.5 mg/kg (maximum: 500 mg) every 6 hours; total duration of therapy 2-3 weeks

Children >5 years: I.M., I.V.: 25-50 mg/kg (maximum: 2 g) every 4-6 hours

(maximum daily dose: 12 g/day) until clinical improvement, followed by oral therapy:

25 mg/kg (maximum: 500 mg) every 6 hours; total duration of therapy 2-3 weeks

Endocarditis (MSSA) (unlabeled dosing): I.V.: 50 mg/kg (maximum: 2 g) every 4 hours for 6 weeks;

give with gentamicin for initial 7 days

Osteomyelitis (MSSA) (unlabeled dosing):

Children 2 months to 5 years: I.M., I.V.: 25-50 mg/kg (maximum: 2 g) every 4-6 hours given

with ceftriaxone until clinical improvement, followed by oral therapy: 12.5 mg/kg (maximum: 500 mg)

every 6 hours; total duration of therapy 3-4 weeks

Children >5 years: I.M., I.V.: 25-50 mg/kg (maximum: 2 g) every 4-6 hours (maximum daily dose: 12 g/day)

until clinical improvement, followed by oral therapy: 25 mg/kg (maximum: 500 mg) every 6 hours;

total duration of therapy 3-4 weeks

Pneumonia (MSSA) (unlabeled dosing):

Children 2 months to 5 years: Oral: 25-50 mg/kg (maximum: 2 g) every 6 hours for at least 3 weeks with gentamicin

Children >5 years: I.M., I.V.: 50 mg/kg (maximum: 2 g) every 6 hours for 10-14 days

Cloxacillin Brands