Mezlocillin

Dose Adult

Moderate to severe infections: 2–4 g IV every 6–8 hours.

Severe Pseudomonas infections: Up to 24 g/day IV in divided doses.

Dose Paeds

150–300 mg/kg/day IV in divided doses every 6–8 hours (maximum according to clinical indication).

Mezlocillin Brands

Brand	Status	Manufacturer	Strength	Formulation	Availability	Price
Baypen® Mezlocillin	Historical	Bayer	1 g	Powder for Injection	Not verified in Kenya	N/A
Baypen® Mezlocillin	Historical	Bayer	2 g	Powder for Injection	Not verified in Kenya	N/A
No currently verified PPB-registered Kenyan Mezlocillin brands identified.

Combinations

May be combined with aminoglycosides for severe Gram-negative infections including Pseudomonas. Administer separately to avoid inactivation.

Mezlocillin More action
Indications	Serious infections caused by susceptible Gram-negative organisms including Pseudomonas aeruginosa, Enterobacter species, urinary tract infections, intra-abdominal infections, septicaemia, biliary tract infections and hospital-acquired infections.
Precautions	History of penicillin allergy, renal impairment, hepatic dysfunction, sodium load in patients with heart failure, prolonged therapy may result in superinfection.
Contraindications	Known hypersensitivity to mezlocillin, penicillins or other beta-lactam antibiotics.
Pregnancy/Lactation	Generally considered low risk during pregnancy when clinically indicated. Compatible with breastfeeding; monitor infant for diarrhoea or candidiasis.
Adverse reaction	Rash, urticaria, diarrhoea, nausea, injection-site reactions, eosinophilia, thrombocytopenia, elevated liver enzymes, anaphylaxis and superinfection.
Polypharmacy	Probenecid may increase serum concentrations. Monitor with warfarin, methotrexate and nephrotoxic drugs. Do not mix with aminoglycosides in the same IV solution.
Drug Category	DRUGS ACTING ON INFECTIONS
Drug Sub-Category	Extended-spectrum Penicillins (Acylureidopenicillins)