Dosing: Adult
Anthrax:Inhalational (postexposure prophylaxis): I.M.: 1,200,000 units every 12 hours
Note: Overall treatment duration should be 60 days.
Available safety data suggest continued administration of penicillin G procaine for longer than 2 weeks
may incur additional risk of adverse reactions. Clinicians may consider switching to effective
alternative treatment for completion of therapy beyond 2 weeks.
Cutaneous (treatment): I.M.: 600,000-1,200,000 units/day; alternative therapy
is recommended in severe cutaneous or other forms of anthrax infection
Endocarditis caused by susceptible viridans Streptococcus (when used in conjunction
with an aminoglycoside): I.M.: 1.2 million units every 6 hours for 2-4 weeks
Gonorrhea (uncomplicated): 4.8 million units as a single dose divided in 2 sites given
30 minutes after probenecid 1 g orally
Neurosyphilis: I.M.: 2.4 million units/day with 500 mg probenecid by mouth 4 times/day for
10-14 days; penicillin G aqueous I.V. is the preferred agent
Whipple's disease: I.M.: 1.2 million units/day (with streptomycin) for 10-14 days, followed
by oral trimethoprim/sulfamethoxazole or doxycycline for 1 year
Dosing: Pediatric
(For additional information see "Penicillin G procaine: Pediatric drug information")
Susceptible infections: I.M.: Infants and Children: 25,000-50,000 units/kg/day in divided doses
1-2 times/day; not to exceed 4.8 million units/24 hours
Anthrax, inhalational (postexposure prophylaxis): I.M.: 25,000 units/kg every 12 hours
(maximum: 1,200,000 units every 12 hours).
Note: Overall treatment duration should be 60 days. Available safety data suggest
continued administration of penicillin G procaine for longer than 2 weeks may incur
additional risk for adverse reactions. Clinicians may consider switching to effective
alternative treatment for completion of therapy beyond 2 weeks.
Syphilis (congenital): I.M.: 50,000 units/kg/day once daily for 10 days; if more than
1 day of therapy is missed, the entire course should be restarted