| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Prednisone | Cosmos Limited. | Cosmos Limited | 5mg | 100 | Tablet | per tablet | KES 225.00 |
| Prednisone | Cosmos Limited. | Cosmos Limited | 5mg | 100 | Tablet | per tablet | KES 225.00 |
| Prednisone | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 5mg | 1000 | Tablet | per tablet | KES 445.00 |
| Prednisone More info | |
|---|---|
| Mode Of Action | It diffuses across cell membranes and forms a complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, binds to DNA, and stimulate transcription of messenger RNA (mRNA). Messenger RNA leads to protein synthesis of various enzymes that are responsible for the effects of systemic corticosteroids |
| Drug Indication | Allergic conditions; rheumatic arthritis; nephrotic syndrome; collagen diseases; fulminating SLE; bronchial asthma; status asthmaticus; severe chronic bronchial asthma; chronic ulcerative colitis; thrombocytopenia; organ transplant; shock (cardiogenic / traumatic). |
| Precautions | Patient monitor if used for prolonged use; use the lowest possible dose; use with caution in patients suffering from diabetes mellitus; CCF; hypertension; infections; thrombo-embolism; elderly; ureamia; and chronic renal failure. |
| Contra-Indications | Hypersensitivity to the drug; systemic fungal infections; live virus vaccination; IM use in idiopathic thrombocytopenic purpura; peptic ulceration; psychosis; osteoporosis; severe psychoneurosis; TB; ocular herpes simplex; primary glaucoma. |
| Side Effects | Hypertension; hypersensitivity reactions; muscle mass loss; osteoporosis; thrombo-embolism; thrombophlebitis; cardiac arrhythmias; insomnia; fatigue; hyperglyceamia; glaucoma; cushoid states; steroid psychosis and aggravation of pre-existing psychiatric conditions; syncopal episodes; GI disorders; impaired wound healing; thin fragile skin; acne; hirsutism; increased appetite and weight gain; convulsions; pancreatitis; spontaneous fractures; increased susceptibility to infections; peptic ulcerati |
| Dosage | Initially up to 10-20mg daily [max. 60mg daily]. Maintenance dose: 2.5-15mg daily. In acute attacks of asthma: High dose prednisolone 30-40mg daily and reduced gradually once the attack is controlled. In chronic asthma: small doses taken in the morning to reduce the interference of circadian cortisol secretion. Child 1 month–18 years initially 1–2mg/kg once daily [usual max. 60 mg daily]. |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | ENDOCRINE DRUGS |
| Drug Sub-Category | Corticosteroids and related drugs |