Dosage ;
Probenecid
| Probenecid more info | |
|---|---|
| Mode Of Action | Probenecid inhibit tubular re-absorption of uric acid and secretion of most penicillins and cephalosporins. |
| Drug Indication | Hyperuricaemia associated with gout and gouty arthritis, elevation and prolongation of plasma level of beta lactam antibiotics. |
| Precautions | Peptic ulcers, renal impairment, the drug may increase the frequency of acute gout attacks during the first 6-12 months of therapy, even when subnormal serum urate concentrations have been maintained, it should be avoided in patients who excrete large amounts of uric acid as it can precipitate the formation of uric acid calculi, monitor acid-base balance, ensure liberal fluid intake. |
| Contra-Indications | Hypersensitivity to probenecid, acute gout, children below 2yrs, blood dyscrasia, uric acid kidney stones. |
| Side Effects | Hypersensitivity reactions, GI disturbances, headache, sore gums, flushing, anaemia, dizziness, renal colic, uric acid stones with or without hematuria, nephrotic syndrome. |
| Dosage | Gout: Initially 250mg 12 hourly for 1/52 then 500mg BD thereafter. Penicillin or cephalosporin therapy: Adult: 2g daily. Children over 2 years, initially 25mg/kg BM, then 40mg/kg /daily in divided doses 6 hourly. |
| Special Information | It is a sulfonamide-derivative. |
| Pregnancy Category | Category B2 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON CNS |
| Drug Sub-Category | Drugs for treatment of gout |