| Mode Of Action | Desferrioxamine forms water soluble complexes with metals. These complexes are easily renally excreted. |
|---|---|
| Drug Indication | Antidote in iron (and other heavy metals) poisoning |
| Contra-Indications | Hypersensitivity to desferrioxamine |
| Side Effects | Anaphylactoid reaction; rashes; local irritation; hypotension; renal disoders; ocular toxicity; ototoxicity; bone marrow depression and growth retardation. |
| Dosage | Acute iron overdose: IV infusion 15mg/kg/hr (until iron serum level is less than 60 micromol/L. Chronic iron overload: Usually maintenance dose in thalassaemia: SC infusion, 1-3g daily over 12-16 hrs 4-6 times weekly |
| Drug Category | DRUGS AFFECTING NUTRITION AND METABOLISM |
| Drug Sub-Category | Antidotes and gastrointestinal decontaminants |