| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Anexate | Roche | Roche Products | 0.5mg | 5 | Injection | per ampoule | KES 23,814 |
| Flumazenil More info | |
|---|---|
| Mode Of Action | Flumazenil is competitive antagonist at benzodiazepine receptors. |
| Drug Indication | Reversal of benzodiazepine sedative effects. Patients may be re-sedated after its administration because the drug has a short-half life - peak effect occurring at 6 to 10 minutes (shorter than midazolam and diazepam); benzodiazepine overdose; hepatic encephalopathy (as it blocks receptor-complex in the brain) |
| Precautions | Avoid rapid administration in bezodiazepine dependent subject as it can lead to severe withdrawal syndrome and seizures. |
| Contra-Indications | Epileptics on prolonged benzodiazepine therapy. Concomittant use with proconvulsant drugs such as theophylline and antihistamines |
| Side Effects | Flushing; nausea and vomiting; transient blood pressure and heart rate increase; fear and anxiety at times due to too rapid awakening; seizures. |
| Dosage | I.V inj, 200mcg over 15secs, followed by 100mcg at 60 secs interval when necessary. Usual dose range 300-600mcg (max 1-2mg) I.V infusion, 100-400 mcg/hr, in case drowsiness occurs after injection. |
| Special Information | It is a 1, 4-imidazobenzodiazepine derivative. It is structurally related to benzodiazepine agonists. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS AFFECTING NUTRITION AND METABOLISM |
| Drug Sub-Category | Antidotes and gastrointestinal decontaminants |