Clonazepam

Dosage ; Adults; Start with low dosage, 1-2mg daily.

Children under 10 years; 0.01-003mg/kg daily. Maintenance dose;

Adult 2-4mg daily. Children 10-16 years: 1.5 - 3mg.

Under 10 years 0.05-0.1mg/kg daily. All as single dose at night.

Clonazepam Brands

Brand Name Manufacturer Name Distributor Drug Strength Packaging Formulation Formulation Strength Price
Leponex Novartis Consumers Harley's Limited 25mg 50 Tablet per tablet KES 2,674.00
Leponex Novartis Consumers Harley's Limited 100mg 50 Tablet per tablet KES 7,607.00
Rivotril Roche Roche Products 0.5mg 50 Tablet per tablet KES 556.00
Rivotril Roche Roche Products 2mg 30 Tablet per tablet KES 705.00

Clonazepam More info
Mode Of Action

Potentiation of the effect of gamma-amino butyrate (GABA). Example: diazepam,
Drug Indication All types of epilepsy (alone or as an adjunct).
Precautions Hepatic / renal / respiratory disorders, other CNS-acting drugs, spinal/cerebral ataxia, alcoholism.
Contra-Indications Pregnancy and lactation, myasthenia gravis, hypersensitivity to the drug.
Side Effects Sedation, ataxia, muscle weakness, loss of libido, paradoxical effects, dependence, double vision, masking of pre-existing depressive illness, floppy infants syndrome if given during labour, GI disturbances.
Dosage Adults; Start with low dosage, 1-2mg daily. Children under 10 years; 0.01-003mg/kg daily. Maintenance dose; Adult 2-4mg daily. Children 10-16 years: 1.5 - 3mg. Under 10 years 0.05-0.1mg/kg daily. All as single dose at night.
Pregnancy Category Category D
Pregnancy Category Description Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required
Drug Category DRUGS ACTING ON CNS
Drug Sub-Category Anticonvulsants

Specific Dosing

Burning mouth syndrome (unlabeled use): Oral: 0.25-3 mg/day in 2 divided doses, in morning and evening.

Seizure disorders: Oral:

Initial daily dose not to exceed 1.5 mg given in 3 divided doses; may increase by 0.5-1 mg every third day until seizures are controlled or adverse effects seen (maximum: 20 mg/day)

Usual maintenance dose: 0.05-0.2 mg/kg; do not exceed 20 mg/day

Panic disorder: Oral: 0.25 mg twice daily; increase in increments of 0.125-0.25 mg twice daily every 3 days; target dose: 1 mg/day (maximum: 4 mg/day)

Discontinuation of treatment: To discontinue, treatment should be withdrawn gradually. Decrease dose by 0.125 mg twice daily every 3 days until medication is completely withdrawn.

Dosing: Pediatric

Seizure disorders (see Use): Oral:

Children <10 years or 30 kg:

Initial daily dose: 0.01-0.03 mg/kg/day (maximum: 0.05 mg/kg/day) given in 2-3 divided doses; increase by no more than 0.5 mg every third day until seizures are controlled or adverse effects seen.

Usual maintenance dose: 0.1-0.2 mg/kg/day divided 3 times/day; not to exceed 0.2 mg/kg/day.

Children >10 years or 30 kg: Refer to adult dosing.

Dosing: Geriatric

Refer to adult dosing. Initiate with low doses and observe closely.

Dosing: Renal Impairment

Hemodialysis: Supplemental dose is not necessary