Dosage ; The dose depends on patient.
Adults- >16 yrs: At first, 500 mg BD (max 3000 mg a day).
Children: 4 - 16 yrs: 20 mg/ kg of body weight in 2 divided doses,
the dose should be increased by 20 mg per kg every
2 weeks until 60 mg per kg is reached
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Keppra | GlaxoSmithkline | GlaxoSmithKline | 250mg | 60 | Tablet | per tablet | KES 3,314.10 |
| Keppra | GlaxoSmithkline | GlaxoSmithKline | 750mg | 60 | Tablet | per tablet | KES 9,801.20 |
| Levipil | Sunlight International Trading (Africa) Co., Ltd | Harley's Limited | 250mg | 30 | Tablet | per tablet | KES 1,450.00 |
| Levipil | Sunlight International Trading (Africa) Co., Ltd | Harley's Limited | 500mg | 30 | Tablet | per tablet | KES 2,400.00 |
| Levipil | Sunlight International Trading (Africa) Co., Ltd | Harley's Limited | 750mg | 30 | Tablet | per tablet | KES 3,750.00 |
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Levetiracetam More info |
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|---|---|
| Mode Of Action | The precise mechanism is unknown. |
| Drug Indication | Adjunctive therapy in the treatment of partial onset seizures in adults and children 4 yrs and older with epilepsy; myoclonic seizures in adults and adolescents 12 years and older with juvenile myoclonic epilepsy and also primary generalized tonic-clonic seizures in adults and children 6 years and older with idiopathic generalized epilepsy. |
| Side Effects | Depression, dizziness, drowsiness, headache, infection, loss of muscle coordination, nervousness, pain, runny nose, sore throat, weakness; psychosis. |
| Dosage | The dose depends on patient. Adults- >16 yrs: At first, 500 mg BD (max 3000 mg a day). Children: 4 - 16 yrs: 20 mg/ kg of body weight in 2 divided doses, the dose should be increased by 20 mg per kg every 2 weeks until 60 mg per kg is reached. |
| Drug Category | DRUGS ACTING ON CNS |
| Drug Sub-Category | Anticonvulsants
Specific Dosages; Dosing: Adult Myoclonic seizures: Oral: Immediate release: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to the recommended dose of 1500 mg twice daily. Efficacy of doses >3000 mg/day has not been established. Partial onset seizures: Oral: Immediate release: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to a maximum of 1500 mg twice daily. Doses >3000 mg/day have been used in trials; however, there is no evidence of increased benefit. Extended release: Initial: 1000 mg once daily; may increase every 2 weeks by 1000 mg/day to a maximum of 3000 mg once daily. I.V.: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to a maximum of 1500 mg twice daily. Doses >3000 mg/day have been used in trials; however, there is no evidence of increased benefit. Note: When switching from oral to I.V. formulations, the total daily dose should be the same. Tonic-clonic seizures: Oral: Immediate release: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to the recommended dose of 1500 mg twice daily. Efficacy of doses >3000 mg/day has not been established. Bipolar disorder (unlabeled use): Oral: Immediate release: Initial: 500 mg twice daily; if tolerated, increase by 500 mg twice daily; dose may be increased every 3 days until target dose of 3000 mg/day is reached; maximum: 4000 mg/day Loading dose (unlabeled): Immediate release: Initial doses of 1500-2000 mg have been well-tolerated (Betts, 2000; Koubeissi, 2008), although the necessity of a loading dose has not been established Dosing: Pediatric Myoclonic seizures: Oral: Children ≥12 years: Immediate release: Initial: 500 mg twice daily; may increase every 2 weeks by 500 mg/dose to the recommended dose of 1500 mg twice daily. Efficacy of doses >3000 mg/day has not been established. Partial onset seizures: Oral: Children 4-15 years: Partial onset seizures: Immediate release: 10 mg/kg/dose given twice daily; may increase every 2 weeks by 10 mg/kg/dose to a maximum of 30 mg/kg/dose twice daily Children ≥16 years: Refer to adult dosing. Tonic-clonic seizures: Oral: Children 6-15 years: Immediate release: Initial: 10 mg/kg dose given twice daily; may increase every 2 weeks by 10 mg/kg/dose to the recommended dose of 30 mg/kg twice daily. Efficacy of doses >60 mg/kg/day has not been established. Children ≥16 years: Refer to adult dosing. Bipolar disorder (unlabeled use): Oral: Children ≥16 years: Refer to adult dosing. Dosing: Geriatric Refer to adult dosing |