Dosage ; Depression: 10mg increasing gradually to 20mg daily in divided doses
or as a single dose at night (max. 250mg daily.
Obsessional and phobic states: 25mg, increasing gradually to 100-150mg daily. Elderly: Initially 10mg daily (max.75mg daily).
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Anafranil | Novartis Consumers | Harley's Limited | 25mg | 30 | Tablet | per tablet | KES 1,150.00 |
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Clomipramine More info |
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|---|---|
| Mode Of Action | The mechanism of action of amitriptylinne is not fully known but may be due to its increasing the synaptic concentration of norepinephrine and/or serotonin in the central nervous system (CNS). These neurotransmitters are thought to be increased through inhibition of their reuptake by the presynaptic neuronal membrane. |
| Drug Indication | Depression disorders; obsessive-compulsive disorders; panic disorders, bulimia nervosa; cataplexy associated with narcolepsy; management of some types of chronic, severe, neurogenic pain. |
| Precautions | Blood monitoring; history of epilepsy; pregnancy and lactation; history of mania; close angle glaucoma; concurrent electroconvulsive therapy; anaesthesia; elderly; hepatic impairment; psychosis; withdraw gradually. |
| Contra-Indications | Severe hepatic disorders; acute recovery phase following myocardial infarction; hypersensitivity to tricyclic drugs; MAOIs. |
| Side Effects | Sexual function impairment, seizures, and nausea and vomiting may occur more frequently with it than with other tricyclic antidepressants. |
| Dosage | Depression: 10mg increasing gradually to 20mg daily in divided doses or as a single dose at night (max. 250mg daily. Obsessional and phobic states: 25mg, increasing gradually to 100-150mg daily. Elderly: Initially 10mg daily (max.75mg daily). |
| Special Information | It has high anticholinergic and sedative effects and moderate to high orthostatic hypotensive effects. |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS ACTING ON CNS |
| Drug Sub-Category | Antidepressants, anxiolytics
Dosing: Adult Treatment of OCD: Oral: Initial: 25 mg/day; may gradually increase as tolerated over the first 2 weeks to 100 mg/day in divided doses; Maintenance: May further increase to recommended maximum of 250 mg/day; may give as a single daily dose at bedtime once tolerated Dosing: Pediatric (For additional information see "Clomipramine: Pediatric drug information") Treatment of OCD: Oral: Children >10 years: Initial: 25 mg/day and gradually increase, as tolerated, to a maximum of 3 mg/kg/day or 100 mg/day (whichever is less). Maintenance: May further increase to recommended maximum of 3 mg/kg/day or 200 mg/day (whichever is less); may give as a single daily dose at bedtime once tolerated. Note: The safety and efficacy of clomipramine in pediatric patients <10 years of age have not been established and, therefore, dosing recommendations cannot be made. Dosing: Geriatric Refer to adult dosing. |