Dosage ; Oral: Initial: 25-150 mg/day at bedtime or in 2-3 divided doses;
may gradually increase up to 300 mg/day;
single dose should not exceed 150 mg;
select patients may respond to 25-50 mg/day.
Dosing: Adult
Depression and/or anxiety: Oral: Initial: 25-150 mg/day at bedtime or in 2-3 divided doses; may gradually increase up to 300 mg/day; single dose should not exceed 150 mg; select patients may respond to 25-50 mg/day.
Insomnia (Silenor®): Oral: 3-6 mg once daily 30 minutes prior to bedtime; maximum dose: 6 mg/day
Dosing: Geriatric
Depression and/or anxiety: Oral: Initial: 10-25 mg at bedtime; increase by 10-25 mg every 3 days for inpatients and weekly for outpatients if tolerated. Rarely does the maximum dose required exceed 75 mg/day; a single bedtime dose is recommended.
Insomnia: Oral: 3 mg once daily 30 minutes prior to bedtime; increase to 6 mg once daily if clinically needed
Dosing: Hepatic Impairment
Use a lower dose and adjust gradually.
Silenor®: Initial: 3 mg once daily
Dosage Forms: U.S.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Capsule, oral: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg
Solution, oral [concentrate]: 10 mg/mL (118 mL, 120 mL)
Tablet, oral:
Silenor®: 3 mg, 6 mg