Dosage ; 50mg is administered initially in a single dose at bedtime.
The dose may be raised in increments of 50 mg a day at intervals of 4-7 days.
Doses above 100mg should be taken in two divided doses.
Usual adult dose: 300mg daily.
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Faverin | Abbott Laboratories | Surgipharm Ltd | 100mg | 30 | Tablet | per tablet | KES 2,502.00 |
| Mode Of Action | Combined serotonin (5-HT) and noradrenaline (NA) re-uptake inhibitor e.g. Duloxetine |
|---|---|
| Drug Indication | Depression; obsessive-compulsive disorders; bulimia nervosa. |
| Precautions | Precautions: Renal impairment; hepatic impairment; withdraw gradually; diabetes; epilepsy; discontinue if seizure develop; elderly; underweight patients as it may lead to massive weight loss; ECT therapy; patients with suicidal tendencies. |
| Contra-Indications | Safety in pregnancy, lactation and children has not been established; severe renal failure; manic phase of depression; within 14 days of MAOI administration; avoid MAOI 5 weeks after discontinuation of fluvoxamine (concurrent use results in confusion, agitation, restlessness, GI symptoms, hyperpyretic episodes, severe convulsions, hypertensive crises, the serotonin syndrome, or death); hypersensitivity to fluvoxamine and related drugs. |
| Side Effects | Sexual dysfunction; mental changes; dyspnea; myoclonus; urinary retention; abnormal bleeding; blurred vision; extrapyramidal effects; hyperkinesias; menstrual changes; seizures; serotonin syndrome; skin rash; syndrome of inappropriate antidiuretic hormone; toxic epidermal necrolysis; galactorrhoea; headache; asthenia; viral or bacterial infections; palpitation; vasodilatation; insomnia; drowsiness; nervousness; anxiety; tremor; decreased heat rate. |
| Dosage | 50mg is administered initially in a single dose at bedtime. The dose may be raised in increments of 50 mg a day at intervals of 4-7 days. Doses above 100mg should be taken in two divided doses. Usual adult dose: 300mg daily. |
| Special Information | Less sedative than tricylics |
| Pregnancy Category | Category B2 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON CNS |
| Drug Sub-Category | Antidepressants, anxiolytics
Dosing: Adult Obsessive-compulsive disorder: Oral: Immediate release: Initial: 50 mg once daily at bedtime; may be increased in 50 mg increments at 4- to 7-day intervals, as tolerated; usual dose range: 100-300 mg/day; maximum dose: 300 mg/day. Note: When total daily dose exceeds 100 mg, the dose should be given in 2 divided doses with larger portion administered at bedtime. Extended release: Initial: 100 mg once daily at bedtime; may be increased in 50 mg increments at intervals of at least 1 week; usual dosage range: 100-300 mg/day; maximum dose: 300 mg/day Social anxiety disorder (unlabeled use): Oral: Extended release: Initial: 100 mg once daily at bedtime; may be increased in 50 mg increments at intervals of at least 1 week; usual dosage range: 100-300 mg/day; maximum dose: 300 mg/day (Davidson, 2004; Stein, 2003; Westenberg, 2004) Post-traumatic stress disorder (PTSD) (unlabeled use):Immediate release: Oral: 75 mg twice daily (Spivak, 2006) Dosing: Pediatric Obsessive-compulsive disorder: Oral: Children 8-17 years: Immediate release: Initial: 25 mg once daily at bedtime; may be increased in 25 mg increments at 4- to 7-day intervals, as tolerated, to maximum therapeutic benefit; usual dose range: 50-200 mg/day. Note: When total daily dose of immediate release exceeds 50 mg, the dose should be given in 2 divided doses with larger portion administered at bedtime. Maximum dose: Children: 8-11 years: 200 mg/day; Adolescents: 300 mg/day; lower doses may be effective in female versus male patients Dosing: Geriatric Reduce dose; titrate slowly |