Clorazepate

Dosage ; 7.5-22.5mg daily in 2-3 divided doses or single dose of 15mg nocte.

The dose is halved in elderly.

Clorazepate Brands
Brand Name Manufacturer Name Distributor Drug Strength Packaging Formulation Formulation Strength Price
Tranxene Roche Roche Products 5mg 30 Tablet per tablet KES 179
Tranxene Roche Roche Products 10mg 30 Tablet per tablet KES 296

Clorazepate More info

Mode Of Action

Potentiation of the effect of gamma-amino butyrate (GABA). Example: diazepam,

Drug Indication Short term use in anxiety and alcohol withdrawal
Dosage 7.5-22.5mg daily in 2-3 divided doses or single dose of 15mg nocte. The dose is halved in elderly.
Drug Category DRUGS ACTING ON CNS
Drug Sub-Category Hypnotics, sedatives & tranquilizers

Specific Dosages

Dosing: Adult

Anxiety: Oral: 7.5-15 mg 2-4 times/day

Ethanol withdrawal: Oral: Initial: 30 mg, then 15 mg 2-4 times/day on first day; maximum daily dose: 90 mg; gradually decrease dose over subsequent days.

Seizures (anticonvulsant): Oral: Initial: Up to 7.5 mg/dose 2-3 times/day; increase dose by 7.5 mg at weekly intervals; not to exceed 90 mg/day

Dosing: Pediatric

(For additional information see "Clorazepate: Pediatric drug information")

Seizures (anticonvulsant): Oral:

Children 9-12 years: Initial: 3.75-7.5 mg/dose twice daily; increase dose by 3.75 mg at weekly intervals, not to exceed 60 mg/day in 2-3 divided doses.

Children >12 years: Refer to adult dosing.

Dosing: Geriatric

Oral: Anxiety: 7.5 mg 1-2 times/day; use is not recommended in the elderly.

Dosage Forms: U.S.

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, oral, as dipotassium: 3.75 mg, 7.5 mg, 15 mg

Tranxene® T-Tab®: 3.75 mg, 7.5 mg, 15 mg [scored]

Generic Equivalent Available: U.S.

Yes

Use

Treatment of generalized anxiety disorder; management of ethanol withdrawal; adjunct anticonvulsant in management of partial seizures

Adverse Reactions Significant

Frequency not defined.