Dose Adult- Dosage Range
Oral
Trichomonas: 1.5 g single dose for one day; alternatively, 0.5 g twice daily for 5 days
Amebiasis (with amebic dysentery): 1.5 g as a single dose for 3 days; patients >60 kg should take 1 g twice daily for 3 days
Giardiasis: 1.5 g as a single dose for 1-2 days
I.V.: Adults:
Anaerobic bacterial infection: Initially infusion of 0.5-1 g followed by 0.5 g every 12 hours for 5-10 days; oral therapy substituted at the earliest opportunity
Amebic liver abscess and severe amebic dysentery: 0.5-1 g, followed by 0.5 g every 12 hours for 3-6 days
Dosage children = Use adult dose if > 35kg
Brands; See below
Combinations;
Ornidazole / Miconazole ; see below
Indications; See dosage area.
Precautions; Peripheral neuropathy, dizziness.
contraindications;
Pregnancy/Lactation; Avoid if possible.
| MOA | ANTI AMOEBIC Ornidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
|---|---|
| Indication | Amoebiasis, trichomoniasis. |
| Side Effects | Dizziness; headache; GI disturbances; reversible peripheral neuropathy. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Amoebics |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Dazolic | Sun Pharmaceuticals Ltd | Sunpar Pharmaceuticals Ltd. | 500mg | 100 | Tablet | per tablet | KES 2,800.00 |
| Granid | NIC Pharma | Medisel Kenya Ltd | 500mg | 10 | Tablet | per tablet | KES 280.00 |
| Granid | NIC Pharma | Medisel Kenya Ltd | 125mg | 30ml | Suspension | per 5ML | KES 210.00 |
| Ordazole | Meyer Organics | Galaxy Pharmaceuticals Ltd | 500mg | 10 | Tablet | per tablet | KES 150.00 |
| Ornidazole / Miconazole | |
|---|---|
| Mode Of Action | Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
| Drug Indication | Mixed vaginal infections, bacterial vaginosis |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Candifem | Meyer Organics | Galaxy Pharmaceuticals Ltd | 500mg/100mg | 6 | Pessaries | KES 330 | |
| Candimale | Meyer Organics | Galaxy Pharmaceuticals Ltd | 2%/2% | 15 | Cream | KES 135.00 |