Ornidazole

Dose Adult- Dosage Range

Oral

Trichomonas: 1.5 g single dose for one day; alternatively, 0.5 g twice daily for 5 days

Amebiasis (with amebic dysentery): 1.5 g as a single dose for 3 days; patients >60 kg should take 1 g twice daily for 3 days

Giardiasis: 1.5 g as a single dose for 1-2 days

I.V.: Adults:

Anaerobic bacterial infection: Initially infusion of 0.5-1 g followed by 0.5 g every 12 hours for 5-10 days; oral therapy substituted at the earliest opportunity

Amebic liver abscess and severe amebic dysentery: 0.5-1 g, followed by 0.5 g every 12 hours for 3-6 days

Dosage children = Use adult dose if > 35kg

Brands; See below

Combinations;

Ornidazole / Miconazole ; see below

Indications; See dosage area.

Precautions; Peripheral neuropathy, dizziness.

contraindications;

Pregnancy/Lactation; Avoid if possible.

MOA

ANTI AMOEBIC Ornidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis

Indication Amoebiasis, trichomoniasis.
Side Effects Dizziness; headache; GI disturbances; reversible peripheral neuropathy.
Drug Category DRUGS ACTING ON INFECTIONS
Drug Sub-Category Anti-Amoebics
Brand Name Manufacturer Name Distributor Drug Strength Packaging Formulation Formulation Strength Price
Dazolic Sun Pharmaceuticals Ltd Sunpar Pharmaceuticals Ltd. 500mg 100 Tablet per tablet KES 2,800.00
Granid NIC Pharma Medisel Kenya Ltd 500mg 10 Tablet per tablet KES 280.00
Granid NIC Pharma Medisel Kenya Ltd 125mg 30ml Suspension per 5ML KES 210.00
Ordazole Meyer Organics Galaxy Pharmaceuticals Ltd 500mg 10 Tablet per tablet KES 150.00
Ornidazole / Miconazole
Mode Of Action

Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis

Drug Indication Mixed vaginal infections, bacterial vaginosis
Brand Name Manufacturer Name Distributor Drug Strength Packaging Formulation Formulation Strength Price
Candifem Meyer Organics Galaxy Pharmaceuticals Ltd 500mg/100mg 6 Pessaries KES 330
Candimale Meyer Organics Galaxy Pharmaceuticals Ltd 2%/2% 15 Cream KES 135.00