Dose Adult - Dosage Range
Oral
Adults: 5–10 mg (10,000–20,000 units) three times daily after meals. Duration depends on indication.
Paediatric use: Safety not well established; not routinely recommended.
Brands; See below
Combinations;
Frequently combined with Aceclofenac, Diclofenac, Nimesulide, Paracetamol + Aceclofenac, Trypsin + Chymotrypsin and other NSAIDs to enhance reduction of inflammation and oedema.
Indications; Post-operative swelling, dental surgery, trauma, sports injuries, ENT inflammation, sinusitis, mastitis, arthritis, painful musculoskeletal conditions and oedematous inflammatory disorders.
Precautions; Use cautiously in bleeding disorders and with anticoagulants.
Contraindications; Hypersensitivity.
Pregnancy/Lactation; Avoid unless clearly indicated.
| MOA | Proteolytic enzyme that hydrolyses inflammatory proteins and facilitates drainage of inflammatory exudates, reducing oedema and pain. |
|---|---|
| Uses | Post-operative oedema, dental extraction, cellulitis adjunct, sinusitis, otitis, trauma, fractures, sprains, arthritis, sports injuries and inflammatory soft tissue disorders. |
| Side Effects | Nausea, abdominal discomfort, diarrhoea, rash, hypersensitivity; rare bleeding. |
| Drug Category | MUSCULOSKELETAL / ANTI-INFLAMMATORY ADJUVANT |
| Drug Sub-Category | Proteolytic Enzyme |
| Brand Name | Manufacturer | Distributor | Strength | Pack | Formulation | Strength Basis | Approx Price |
|---|---|---|---|---|---|---|---|
| Emanzen Forte | Translite/Various | Kenyan distributors | 10 mg | 30 | Tablet | per tablet | KES 900–1,500 |
| Pepdase | Various | Various | 10 mg | 10 | Tablet | per tablet | KES 300–700 |
| Acepar-SP | Various | Various | Aceclofenac+Paracetamol+Serratiopeptidase | 10 | Tablet | per tablet | KES 450–900 |
| Diclofenac + Serratiopeptidase | Various | Various | 50 mg/10 mg | 10 | Tablet | per tablet | KES 350–700 |