Dose Adult- IV or Oral = 400mg OD for 7-10 days
Indications
Acute bacterial sinusitis: Oral, I.V.: 400 mg every 24 hours for 10 days
Chronic bronchitis, acute bacterial exacerbation: Oral, I.V.: 400 mg every 24 hours for 5 days
Intra-abdominal infections, complicated: 400 mg every 24 hours for 5-14 days (initiate with I.V.); Note: 2010 IDSA guidelines recommend a treatment duration of 4-7 days (provided source controlled) for community-acquired, mild-to-moderate IAI
Pneumonia, community-acquired (including MDRSP): Oral, I.V.: 400 mg every 24 hours for 7-14 days
Skin and skin structure infections: Oral, I.V.:
Complicated: 400 mg every 24 hours for 7-21 days
Uncomplicated: 400 mg every 24 hours for 7 days
Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Apdrop | Ajanta Pharmaceuticals Ltd | Harley's Limited | 5mg | 3ml | eye drops | per ml | KES 431.00 |
| Vigamox | Alcon Pharmaceuticals | Pan Pharmaceuticals Ltd | 5mg | 5ml | eye drops | per ml | KES 2,430.00 |
| Avelon | Bayer Schering Pharma | Bayer East Africa Ltd. | 400mg | 5 | Tablet | per tablet | KES 992.73 |
| Avelon | Bayer Schering Pharma | Bayer East Africa Ltd. | 400mg | 10 | Tablet | per tablet | KES 1,985.07 |
| Avelox | Bayer Schering Pharma | Bayer East Africa Ltd. | 400mg | 5 | Tablet | per tablet | KES 1,230.37 |
| Avelox | Bayer Schering Pharma | Bayer East Africa Ltd. | 400mg | 10 | Tablet | per tablet | KES 2,459.40 |
| Avelox | Bayer Schering Pharma | Bayer East Africa Ltd. | 400mg | 250ml | Injection | per ampoule | KES 3,932.25 |
| M-Flox | Hetero Drugs Ltd | Unisel Pharma (K) Ltd. | 400mg | 10 | Tablet | per tablet | KES 1,390.00 |
| Micromox | Micro - Labs Limited | Pharma Specialities Ltd. | 400mg | 15 | Tablet | per tablet | KES 3,159.00 |
| Maxim | Jamjoom Pharma | Pharma Specialities Ltd. | 400mg | 5 | Tablet | per tablet | KES 1,044.00 |
| Maxim | Jamjoom Pharma | Pharma Specialities Ltd. | 400mg | 7 | Tablet | per tablet | KES 1,444.00 |
| Moxicip | Cipla Ltd. | Surgipharm Ltd | 400mg | 5 | Tablet | per tablet | KES 950.00 |
| Moxiget | Getz Pharmaceuticals | Surgipharm Ltd | 400mg | 5 | Tablet | per tablet | KES 1,140.00 |
| Moxiget | Getz Pharmaceuticals | Surgipharm Ltd | 400mg | 250ml | Injection | per ml | KES 1,587.00 |
| Moximac | Macleods Pharmaceuticals Ltd. | Sai Pharmaceuticals Ltd. | 400mg | 5 | Tablet | per tablet | KES 1,022.00 |
| Moxilon | Cipla Ltd. | Surgipharm Ltd | 400mg | 5 | Tablet | per tablet | KES 1,207.50 |
| Moxilon | Cipla Ltd. | Surgipharm Ltd | 4mg | 100ml | Injection | per ml | KES 1,092.50 |
| Moxi-Bio | Sava Medica Limited | Eurox Pharmaceuticals Ltd. | 400mg | 5 | Tablet | per tablet | KES 1,025.00 |
| Zeebact | Synermed Pharmaceuticals Ltd | Saicare Enterprises Ltd. | 400mg | 5 | Tablet | per tablet | KES 950.00 |
Moxifloxacin more information
| Mode Of Action | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
|---|---|
| Drug Indication | E.N.T., UTI, RTI, skin and soft tissues, bone, joint, GI, intra-abdominal, pelvic and severe infections, gonorrhea. |
| Precautions | Quinolones should be used with caution in children with a history of epilepsy or conditions that predispose to seizures, in G6PD deficiency, myasthenia gravis (risk of exacerbation). Exposure to excessive sunlight should be avoided (discontinue if photosensitivity occurs). Quinolones may induce convulsions in patients with or without a history of convulsions; taking NSAIDs at the same time may also induce them. May cause arthropathy in the weight-bearing joints of immature animals and are therefore generally not recommended in children and growing adolescents. However, the significance of this effect in humans is uncertain and in some specific circumstances short-term use of a quinolone in children is justified. Should be avoid in pregnancy and lactation. |
| Contra-Indications | History of tendon disorders related to quinolone use, documented hypersensitivity. |
| Side Effects | GI disturbances, dizziness, headache, tremor, confusion, convulsions, rashes, blurred vision, psychotic reactions, impaired vision, impaired taste and smell sensation, stevens-johnson syndrome, hot flushes, skin rashes, migraine, photosensitivity. |
| Dosage | It may be given orally, or by intravenous infusion over 60 minutes. Usual dose is 400 mg once daily. |
| Pregnancy Category | Category B3 Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |