Dose Adult- 400mg BDx7 days most infections; 2weeks if prostatitis;
gonorrhoea=800mg Single dose
Dose Paeds-Avoid due to arthropathy.
Combinations;
Norfloxacin/ Tinidazole
Indications; UTI, GIT infections, Gonorrhoea
Precautions; Seizure and Photosensitivity patients
contraindications; G6PD, Mysthenia Gravis,
Pregnancy/Lactation;Category B3
Adverse reaction; May cause artheropathy in children/ adolescents at growth plate.
Polypharmacy; Avoid with NSAIDS
| Norfloxacin | |
|---|---|
| Drug Sub-Category | Fluoroquinolones |
| Mode Of Action | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
| Drug Indication | See under dose |
| Precautions | Quinolones should be used with caution in children with a history of epilepsy or conditions that predispose to seizures, in G6PD deficiency, myasthenia gravis (risk of exacerbation). Exposure to excessive sunlight should be avoided (discontinue if photosensitivity occurs). Quinolones may induce convulsions in patients with or without a history of convulsions; taking NSAIDs at the same time may also induce them. May cause arthropathy in the weight-bearing joints of immature animals and are therefore generally not recommended in children and growing adolescents. However, the significance of this effect in humans is uncertain and in some specific circumstances short-term use of a quinolone in children is justified. Should be avoid in pregnancy and lactation. |
| Contra-Indications | History of tendon disorders related to quinolone use, documented hypersensitivity. |
| Side Effects | Tinnitus, epiphora; rarely pancreatitis; very rarely arrhythmias; also reported polyneuropathy and exfoliative dermatitis. |
| Dosage | Lower urinary-tract infections, 400mg twice daily for 7-10 days (for 3 days for uncomplicated infections in women). Chronic relapsing lower urinary-tract infections, 400mg twice daily for up to 12 weeks; may be reduced to 400mg once daily if adequate suppression within first 4 weeks. Chronic prostatitis, 400mg twice daily for 28 days. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |