Dasage Oral: 400 mg twice daily; taken with food
Ophthalmic: 1-2 drops in affected eye(s) 2-6 times/day, depending on severity of infection
Orally, 400 mg twice daily. A single dose of 800 mg may be used in the treatment of gonococcal urethritis in men and acute uncomplicated cystitis in women.
I.V.: 400 mg twice daily given by slow infusion over 1 hour
Brands
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Pefaxin | Emil Pharmaceuticals | Sai Pharmaceuticals Ltd. | 400mg | 20 | Tablet | per tablet | KES 220.00 |
| Peflobid | Cadila Pharmaceuticals Ltd. | Cadila Pharmaceuticals (EA) | 400mg | 10 | Tablet | per tablet | KES 380.00 |
| Pefloma | Plethico Pharmaceuticals Ltd. | Beta Healthcare International Ltd | 400mg | 10 | Tablet | per tablet | KES 60.00 |
| Pelox | Wockhardt International | Pharma Specialities Ltd. | 1000mg | 5 | Suppositories | KES 120 | |
| Pelox | Wockhardt International | Pharma Specialities Ltd. | 2000mg | 5 | KES 130 | ||
| Pelox | Wockhardt International | Pharma Specialities Ltd. | 12 | infusion | per ml | KES 240 | |
| Pelox | Wockhardt International | Pharma Specialities Ltd. | 12 | infusion | per ml | KES 100 |
Moxifloxacin more information
| Pefloxacin | |
|---|---|
| Mode Of Action | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
| Drug Indication | Severe infection in adults due to Staphylococcus and Gram-negative bacilli. |
| Precautions | Quinolones should be used with caution in children with a history of epilepsy or conditions that predispose to seizures, in G6PD deficiency, myasthenia gravis (risk of exacerbation). Exposure to excessive sunlight should be avoided (discontinue if photosensitivity occurs). Quinolones may induce convulsions in patients with or without a history of convulsions; taking NSAIDs at the same time may also induce them. May cause arthropathy in the weight-bearing joints of immature animals and are therefore generally not recommended in children and growing adolescents. However, the significance of this effect in humans is uncertain and in some specific circumstances short-term use of a quinolone in children is justified. Should be avoid in pregnancy and lactation. |
| Contra-Indications | History of tendon disorders related to quinolone use, documented hypersensitivity. |
| Side Effects | Flatulence, pain and phlebitis at injection site; rarely dysphagia, pancreatitis, chest pain, tachycardia, syncope, oedema, hot flushes, abnormal dreams, sweating, hyperglycaemia, and erythema nodosum; very rarely movement disorders, tinnitus, vasculitis, and tenosynovitis. |
| Dosage | Orally, 400 mg twice daily. A single dose of 800 mg may be used in the treatment of gonococcal urethritis in men and acute uncomplicated cystitis in women. |
| Pregnancy Category Description | Drugs that can cause closure of ductus arteriosus in fetus when used in the Third Trimester |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Fluoroquinolones |