Dose Adult- 200 mg daily to 400 mg twice daily depending on the severity and the nature of the infection.
Dose Paeds- Avoid due to toxicity to growth plate.
Combinations; Ofloxacin / Dexamethasone
Ofloxacin / Ornidazole, (Antiamoebic)
Indications; Chlamydia, Non complicated Gonorrhoea, uncomplicated cystitis,
leprosy in combination.
Precautions; Seizure and Photosensitivity patients,
Symptomatic hyperglycaemia and/or hypoglycaemia have been reported,
usually in diabetics who are also taking hypoglycaemics or insulin
contraindications; Pregnancy, lactation, cerebral convulsive disorders, children.
Pregnancy/Lactation; Category B3
Polypharmacy
| Ofloxacin | |
|---|---|
| Category | Fluoroquinolones |
| MOA | interferes with bacterial DNA synthesis by inhibiting topoisomerase II (DNA gyrase) and topoisomerase IV. |
| Indication | See under indications and doses. |
| Precautions | Symptomatic hyperglycaemia and/or hypoglycaemia have been reported, usually in diabetics who are also taking hypoglycaemics or insulin. Such patients should have their blood-glucose concentrations closely monitored and if signs or symptoms of glucose disturbances develop, ofloxacin should be stopped. A reduction in blood pressure may occur rarely after intravenous infusion. Similarly, sudden reductions in blood pressure may occur when intravenous ofloxacin is given with hypotensive drugs. Cardiovascular function should be monitored in such patients and in those also receiving barbiturate anaesthetics. It should not be used for more than 10 days. |
| Contra-Indications | Pregnancy, lactation, cerebral convulsive disorders, children. |
| Side Effects | Allergic reactions, GI disturbances, muscular and joint pains, blood dyscrasias, CNS effects, muscular co-ordination disturbances, visual and sensory disturbances, hallucinations, convulsions, psychotic reactions. For injection, decreased BP especially by rapid infusion. |
| Dosage | Used in Chlamydia or Chlamydophila infections including nongonococcal urethritis and in mycobacterial infections such as leprosy and tuberculosis (see under uses and administration of ciprofloxacin). Ofloxacin is given orally as the base or by intravenous infusion as the hydrochloride. The usual oral or intravenous dose ranges from 200 mg daily to 400 mg twice daily depending on the severity and the nature of the infection. Oral doses of up to 400 mg may be given as a single dose, preferably in the morning. For intravenous use a 0.2% solution is infused over 30 minutes. An oral dose of 200 mg twice daily for 3 days is suitable in women with acute uncomplicated cystitis. A 6-week course of treatment with an oral dose of 300 mg twice daily should be given for chronic bacterial prostatitis. Oral doses of 400 mg daily with clofazimine and minocycline or 400 mg monthly with rifampicin and minocycline have been recommended by WHO as alternative multidrug therapy regimens for multibacillary leprosy. As an alternative regimen for single-lesion paucibacillary leprosy WHO suggests a single dose of ofloxacin 400 mg with rifampicin and minocycline. A single 400-mg dose of ofloxacin may be given orally for uncomplicated gonorrhoea. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTING ON INFECTIONS |